Research on gene editing and immunosuppressants in kidney xenotransplantation

被引：0

作者：

Luo, Jiajiao ^{[1
]}

Bian, Congwen ^{[1
]}

Liu, Min ^{[1
]}

Fang, Yuan ^{[1
]}

Jin, Li ^{[1
]}

Yu, Rui ^{[1
]}

Huang, Hanfei ^{[1
]}

机构：

[1] Kunming Med Univ, Affiliated Hosp 1, Dept Organ Transplantat, Kunming, Yunnan, Peoples R China

来源：

TRANSPLANT IMMUNOLOGY | 2025年 / 89卷

关键词：

Xenotransplantation; Gene editing; Immunotherapy; NHP; Kidney xenotransplantation; DECAY-ACCELERATING FACTOR; TRANSGENIC EXPRESSION; COMPLEMENT ACTIVATION; ISCHEMIA-REPERFUSION; CELL DEPLETION; CD39; PROTECTS; PIG; KNOCKOUT; LIVER; REJECTION;

D O I：

10.1016/j.trim.2025.102184

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gene-edited pig organ transplantation can solve the serious shortage of human donor organs. Currently, xenotransplantation is rapidly developing and has made significant breakthroughs. The use of GTKO (Gal knockout) pigs is an important step forward. The subsequent knockout of three genes combined with the transfer of immune-related genes effectively prolonged the survival time of non-human primate (NHP) transplantation in xenotransplantation. Due to the success of allogeneic kidney transplantation on NHP, this gene editing protocol was recently applied to clinical patients. Two patients underwent allogeneic kidney transplantation and survived for 51 days and 47 days. Exceeding the hyperacute rejection period proves that appropriate gene editing strategies and the combination of immunosuppressive agents contribute to the success of xenotransplantation. To further enhance the feasibility of pig kidney xenograft, this article mainly explores the effects of the NHP xenograft gene editing scheme and immunosuppressants on prolonging transplant survival time.

引用

页数：7

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