Isolation of four new phenolic compounds from the fungus Talaromyces cellulolyticus

Four new phenolic compounds talarocelic A-D (1-4), together with four known compounds (5-8) were isolated from the fungus Talaromyces cellulolyticus CBS136886. Their chemical structures were elucidated through extensive spectroscopic data analysis such as HR-ESI-MS, UV, IR, and 1D- and 2D-NMR. Biological assay results revealed that compound 6 displayed potent protein tyrosine phosphatase 1B and alpha-glucosidase inhibitory activities with inhibition rates of 91.7 % and 59.6 %, respectively, at 10 mu M. In addition, compound 6 showed moderate anti-inflammatory activity with 56.4 % inhibition at 10 mu M and anti-bacterial activity against Staphylococcus aureus with a minimum inhibitory concentration of 12.5 mu g/mL. This work not only reveals that T. cellulolyticus is rich in phenolic compounds but also provides access to diverse bioactive lead compounds for drug discovery.