The impact of COVID-19 severity on adult survivors: Is there a relationship between vascular reactivity and cardiorespiratory fitness?

被引:0
作者
Back, Guilherme Dionir [1 ]
Oliveira, Murilo Rezende [1 ]
Areas, Guilherme Peixoto Tinoco [2 ,3 ]
Camargo, Patricia Faria [1 ]
da Luz Goulart, Cassia [1 ]
de Oliveira, Claudio Ricardo [1 ]
Bonjorno Jr, Jose Carlos [1 ]
Bonjourno, Flavia Rossi Caruso [1 ]
Arena, Ross [4 ]
Borghi-Silva, Audrey [1 ]
机构
[1] Univ Fed Sao Carlos, Physiotherapy Dept, Cardiopulm Physiotherapy Lab, UFSCar, Sao Carlos, Brazil
[2] Univ Fed Amazonas, Coll Phys Educ & Physiotherapy FEFF, Exercise Physiol Lab, Manaus, Brazil
[3] Univ Brasilia, Coll Phys Educ, Brasilia, Brazil
[4] Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, Chicago, IL USA
来源
PHYSIOLOGICAL REPORTS | 2025年 / 13卷 / 05期
基金
巴西圣保罗研究基金会;
关键词
cardiopulmonary testing; COVID-19; endothelial function; survivors; EXERCISE; INDEX; POWER;
D O I
10.14814/phy2.70216
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The impact of COVID-19 on cardiorespiratory fitness (CRF) is negative, increasing the likelihood of exertional symptoms such as fatigue and shortness of breath, and adversely affecting vascular function, impairing cardiovascular health. This study investigated endothelial function and its relationship with CRF in patients who have recovered COVID-19. Patients were evaluated 1 month after infection, including clinical assessment, pulmonary function, endothelial function (measured by flow-mediated dilation), and cardiopulmonary exercise testing. COVID-19 survivors exhibited reduced exercise capacity, with poor values of peak <(V)over dot>O(2peak )and FMD (%) according to disease severity. However, endothelial function was worse in COVID-19 patients, regardless of severity, compared to the control group. Significant associations were observed between poorer FMD (%) and peak <(V)over dot>O-2peak, workload, circulatory power, and <(V)over dot>O-2peak/WR. Endothelial function was significantly associated with CRF in COVID-19 patients according to disease severity. Strategies to improve CRF and reduce the negative impacts of endothelial function damage should be further investigated.
引用
收藏
页数:12
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