Gene Therapy and Gene Editing: Current Trends and Future Prospects of Molecular Medicine
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作者:
Sen, Aniruddha
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All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Sen, Aniruddha
[1
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Singh, Vijay
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All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Singh, Vijay
[1
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Dwivedi, Shailendra
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All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Dwivedi, Shailendra
[1
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Agrawal, Ruchika
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All India Inst Med Sci Gorakhpur, Dept ENT, Gorakhpur 273008, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Agrawal, Ruchika
[2
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Bansal, Akash
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All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Bansal, Akash
[1
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Shekhar, Shashank
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All India Inst Med Sci, Dept Radiotherapy, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Shekhar, Shashank
[3
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Kushwaha, Sudhir Shyam
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All India Inst Med Sci Gorakhpur, Dept Orthopaed, Gorakhpur 273008, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Kushwaha, Sudhir Shyam
[4
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机构:
[1] All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
[2] All India Inst Med Sci Gorakhpur, Dept ENT, Gorakhpur 273008, India
[3] All India Inst Med Sci, Dept Radiotherapy, Gorakhpur 273008, Uttar Pradesh, India
[4] All India Inst Med Sci Gorakhpur, Dept Orthopaed, Gorakhpur 273008, India
Gene therapy and genome editing have emerged as transformative approaches in the management of a diverse range of genetic and acquired diseases. This evaluation offers a thorough examination of the present state and prospects of these innovative technologies. Gene therapy is a prospective approach to the treatment and prevention of a variety of conditions, including complex cancers and inherited genetic disorders, which entail the introduction, removal, or modification of genetic material within a patient's cells. Genome editing, particularly through techniques such as CRISPR-Cas9, enables targeted corrections of genetic defects and opens new possibilities for personalized medicine by allowing for precise modifications at the DNA level. The review addresses the ethical implications, clinical applications, and significant advancements of these technologies. This article endeavors to underscore the substantial influence of gene therapy and genome editing on contemporary medicine by assessing the most recent research and clinical trials, thereby emphasizing their potential to revolutionize disease treatment and management.
机构:
Zhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Tang, Wantao
Tong, Ting
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Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Tong, Ting
Wang, Hong
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Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Wang, Hong
Lu, Xuehe
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Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Lu, Xuehe
Yang, Changping
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机构:
Zhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Yang, Changping
Wu, Yushuai
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机构:
Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R China
Univ Chinese Acad Sci, Beijing 100049, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Wu, Yushuai
Wang, Yuang
论文数: 0引用数: 0
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机构:
Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Wang, Yuang
Liu, Jianbing
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Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R China
Univ Chinese Acad Sci, Beijing 100049, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Liu, Jianbing
Ding, Baoquan
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Zhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarch Fabricat, Beijing 100190, Peoples R China
Univ Chinese Acad Sci, Beijing 100049, Peoples R ChinaZhengzhou Univ, Sch Mat Sci & Engn, Zhengzhou 450001, Peoples R China
机构:
RAS, Inst Cytol, St Petersburg 194064, RussiaRAS, Inst Cytol, St Petersburg 194064, Russia
Shuvalov, Oleg
Petukhov, Alexey
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RAS, Inst Cytol, St Petersburg 194064, Russia
St Petersburg State Technol Inst, St Petersburg 190013, Russia
Fed North West Med Res Ctr, Inst Hematol, St Petersburg, RussiaRAS, Inst Cytol, St Petersburg 194064, Russia
Petukhov, Alexey
Daks, Alexandra
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RAS, Inst Cytol, St Petersburg 194064, RussiaRAS, Inst Cytol, St Petersburg 194064, Russia
Daks, Alexandra
Fedorova, Olga
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RAS, Inst Cytol, St Petersburg 194064, RussiaRAS, Inst Cytol, St Petersburg 194064, Russia
Fedorova, Olga
Ermakov, Alexander
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RAS, Inst Cytol, St Petersburg 194064, RussiaRAS, Inst Cytol, St Petersburg 194064, Russia
Ermakov, Alexander
Melino, Gerry
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机构:
St Petersburg State Technol Inst, St Petersburg 190013, Russia
Univ Roma Tor Vergata, I-00133 Rome, ItalyRAS, Inst Cytol, St Petersburg 194064, Russia
Melino, Gerry
Barlev, Nickolai A.
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RAS, Inst Cytol, St Petersburg 194064, RussiaRAS, Inst Cytol, St Petersburg 194064, Russia
机构:
The Center for Fetal Research, The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., ARC 1116E, Philadelphia, 19104, PAThe Center for Fetal Research, The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., ARC 1116E, Philadelphia, 19104, PA
Hartman H.A.
Rossidis A.C.
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The Center for Fetal Research, The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., ARC 1116E, Philadelphia, 19104, PAThe Center for Fetal Research, The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., ARC 1116E, Philadelphia, 19104, PA
Rossidis A.C.
Peranteau W.H.
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The Center for Fetal Research, The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., ARC 1116E, Philadelphia, 19104, PAThe Center for Fetal Research, The Children’s Hospital of Philadelphia, 3615 Civic Center Blvd., ARC 1116E, Philadelphia, 19104, PA