Gene Therapy and Gene Editing: Current Trends and Future Prospects of Molecular Medicine
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作者:
Sen, Aniruddha
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All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Sen, Aniruddha
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Singh, Vijay
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All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Singh, Vijay
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Dwivedi, Shailendra
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All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Dwivedi, Shailendra
[1
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Agrawal, Ruchika
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All India Inst Med Sci Gorakhpur, Dept ENT, Gorakhpur 273008, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Agrawal, Ruchika
[2
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Bansal, Akash
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All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Bansal, Akash
[1
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Shekhar, Shashank
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All India Inst Med Sci, Dept Radiotherapy, Gorakhpur 273008, Uttar Pradesh, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Shekhar, Shashank
[3
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Kushwaha, Sudhir Shyam
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All India Inst Med Sci Gorakhpur, Dept Orthopaed, Gorakhpur 273008, IndiaAll India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
Kushwaha, Sudhir Shyam
[4
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机构:
[1] All India Inst Med Sci, Dept Biochem, Gorakhpur 273008, Uttar Pradesh, India
[2] All India Inst Med Sci Gorakhpur, Dept ENT, Gorakhpur 273008, India
[3] All India Inst Med Sci, Dept Radiotherapy, Gorakhpur 273008, Uttar Pradesh, India
[4] All India Inst Med Sci Gorakhpur, Dept Orthopaed, Gorakhpur 273008, India
Gene therapy and genome editing have emerged as transformative approaches in the management of a diverse range of genetic and acquired diseases. This evaluation offers a thorough examination of the present state and prospects of these innovative technologies. Gene therapy is a prospective approach to the treatment and prevention of a variety of conditions, including complex cancers and inherited genetic disorders, which entail the introduction, removal, or modification of genetic material within a patient's cells. Genome editing, particularly through techniques such as CRISPR-Cas9, enables targeted corrections of genetic defects and opens new possibilities for personalized medicine by allowing for precise modifications at the DNA level. The review addresses the ethical implications, clinical applications, and significant advancements of these technologies. This article endeavors to underscore the substantial influence of gene therapy and genome editing on contemporary medicine by assessing the most recent research and clinical trials, thereby emphasizing their potential to revolutionize disease treatment and management.
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Icahn Sch Med Mt Sinai, Tisch Canc Inst, One Gustave Levy Pl, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Tisch Canc Inst, One Gustave Levy Pl, New York, NY 10029 USA
Ward, Peter
Walsh, Christopher E.
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Icahn Sch Med Mt Sinai, Tisch Canc Inst, One Gustave Levy Pl, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Tisch Canc Inst, One Gustave Levy Pl, New York, NY 10029 USA
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St Jude Childrens Res Hosp, Dept Oncol, 262 Danny Thomas Pl,MS 355, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Oncol, 262 Danny Thomas Pl,MS 355, Memphis, TN 38105 USA
Christakopoulos, Georgios E.
Telange, Rahul
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St Jude Childrens Res Hosp, Dept Hematol, 262 Danny Thomas Pl,MS 355, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Oncol, 262 Danny Thomas Pl,MS 355, Memphis, TN 38105 USA
Telange, Rahul
Yen, Jonathan
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St Jude Childrens Res Hosp, Dept Hematol, 262 Danny Thomas Pl,MS 355, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Oncol, 262 Danny Thomas Pl,MS 355, Memphis, TN 38105 USA
Yen, Jonathan
Weiss, Mitchell J.
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St Jude Childrens Res Hosp, Dept Hematol, 262 Danny Thomas Pl,MS 355, Memphis, TN 38105 USASt Jude Childrens Res Hosp, Dept Oncol, 262 Danny Thomas Pl,MS 355, Memphis, TN 38105 USA
机构:
West Virginia Univ, Ctr Neurosci, Robert C Byrd Hlth Sci Ctr, Morgantown, WV 26505 USAWest Virginia Univ, Ctr Neurosci, Robert C Byrd Hlth Sci Ctr, Morgantown, WV 26505 USA
Ku, Cristy A.
Pennesi, Mark E.
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Oregon Hlth & Sci Univ, Casey Eye Inst, Portland, OR 97239 USAWest Virginia Univ, Ctr Neurosci, Robert C Byrd Hlth Sci Ctr, Morgantown, WV 26505 USA