A synthetic molecule targeting STAT3 against human oral squamous cell carcinoma cells

被引：1
作者：
Bai, Li-Yuan [1 ,2 ]
Dokla, Eman M. E. [3 ]
Chu, Po-Chen [4 ,5 ]
Feng, Chia-Hsien [6 ]
Hu, Jing-Lan [1 ]
Wang, Liang-Jun [7 ]
Weng, Jing-Ru [7 ,8 ,9 ]
机构：
[1] China Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Taichung 404, Taiwan
[2] China Med Univ, Coll Med, Taichung 404, Taiwan
[3] Ain Shams Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11566, Egypt
[4] China Med Univ, Dept Cosmeceut, Taichung 404, Taiwan
[5] China Med Univ, Grad Inst Cosmeceut, Taichung 404, Taiwan
[6] Kaohsiung Med Univ, Coll Pharm, Dept Fragrance & Cosmet Sci, Kaohsiung 807, Taiwan
[7] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[8] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[9] Taipei Med Univ, Grad Inst Pharmacognosy, Coll Pharm, Taipei 110, Taiwan
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2025年 / 22卷 / 05期
关键词：
Oral squamous cell carcinoma; apoptosis; migration; MAPK; STAT3; TYROSINE KINASE INHIBITOR; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER CELLS; KAPPA-B; GROWTH; RECEPTOR; EXPRESSION; ACTIVATION; PATHWAY; HEAD;
D O I：
10.7150/ijms.105200
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Oral squamous cell carcinoma (OSCC), one of the most common cancers in Taiwan, needs new therapeutic agents and treatments. The aim of this study was to investigate the anti-proliferative activity of nyl]-1,2,4-oxadiazol-3-yl]phenyl]-3-pyridine-carboxamide} (COC), a synthetic molecule, in OSCC cells. COC exhibits potent tumor-suppressive efficacy with IC50 values of 195 nM and 204 nM toward SCC2095 and SCC4 OSCC cells, respectively. Our data revealed that COC caused caspase-dependent apoptosis and downregulated the MAPK signaling pathway. In addition, COC modulated the levels of E-cadherin and beta-catenin and inhibited migration. COC also decreased p-STAT3 levels, and the overexpression of STAT3 partially attenuated COC-induced cytotoxicity. Therefore, our findings suggest the use of COC as a new approach to oral cancer treatment.
引用
收藏
页码：1081 / 1091
页数：11
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