Retinoic acid modulates peripheral blood helper innate lymphoid cell composition in vitro in patients with multiple sclerosis

被引：0

作者：

Ozkosar, Altug ^{[1
]}

Oktelik, Fatma Betul ^{[2
]}

Gelmez, Metin Yusuf

Erden, Sevda Ozturk ^{[3
]}

Gunduz, Tuncay ^{[3
]}

Kurtuncu, Murat ^{[3
]}

Deniz, Gunnur ^{[2
]}

Cinar, Suzan ^{[2
]}

机构：

[1] Istanbul Univ, Inst Grad Studies Hlth Sci, Istanbul, Turkiye

[2] Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Immunol, Vakif Gureba St, Istanbul, Turkiye

[3] Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkiye

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2025年 / 398卷

关键词：

Multiple sclerosis; Innate lymphoid cell; Interleukin-10; Retinoic acid; Innate lymphoid cell plasticity; EXPRESSION; TISSUE;

D O I：

10.1016/j.jneuroim.2024.578489

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study investigates the frequency and numbers of circulating helper innate lymphoid cells (ILCs) in untreated relapsing-remitting multiple sclerosis (RRMS) patients, focusing on intracellular IL-10 and CCR6 expressions under IL-2, IL-33, and retinoic acid (RA) stimulation in vitro and their associations with clinical features in RRMS. In RRMS patients, ILC1 levels were notably higher upon IL-2 + IL-33 + RA stimulation, while ILC2 levels, particularly the c-Kit+ ILC2 and CCR6+ ILC2 subsets, were significantly lower compared to unstimulated conditions. Additionally, IL-10+ ILC1 levels were elevated. The ratios of IL-10+ ILC1/ILC1, c-Kit+ ILC2/c-Kit- ILC2, and CCR6+ ILC2/ILC2 were associated with the progression index (PI) in RRMS patients.

引用

页数：11

共 32 条

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[32] The role of meningeal populations of type II innate lymphoid cells in modulating neuroinflammation in neurodegenerative diseases
Yeung, Sherry Sin-Hang
Ho, Yuen-Shan
Chang, Raymond Chuen-Chung
[J]. EXPERIMENTAL AND MOLECULAR MEDICINE, 2021, 53 (09) : 1251 - 1267

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