Retinoic acid modulates peripheral blood helper innate lymphoid cell composition in vitro in patients with multiple sclerosis

被引：0
作者：
Ozkosar, Altug [1 ]
Oktelik, Fatma Betul [2 ]
Gelmez, Metin Yusuf
Erden, Sevda Ozturk [3 ]
Gunduz, Tuncay [3 ]
Kurtuncu, Murat [3 ]
Deniz, Gunnur [2 ]
Cinar, Suzan [2 ]
机构：
[1] Istanbul Univ, Inst Grad Studies Hlth Sci, Istanbul, Turkiye
[2] Istanbul Univ, Aziz Sancar Inst Expt Med, Dept Immunol, Vakif Gureba St, Istanbul, Turkiye
[3] Istanbul Univ, Istanbul Fac Med, Dept Neurol, Istanbul, Turkiye
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2025年 / 398卷
关键词：
Multiple sclerosis; Innate lymphoid cell; Interleukin-10; Retinoic acid; Innate lymphoid cell plasticity; EXPRESSION; TISSUE;
D O I：
10.1016/j.jneuroim.2024.578489
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This study investigates the frequency and numbers of circulating helper innate lymphoid cells (ILCs) in untreated relapsing-remitting multiple sclerosis (RRMS) patients, focusing on intracellular IL-10 and CCR6 expressions under IL-2, IL-33, and retinoic acid (RA) stimulation in vitro and their associations with clinical features in RRMS. In RRMS patients, ILC1 levels were notably higher upon IL-2 + IL-33 + RA stimulation, while ILC2 levels, particularly the c-Kit+ ILC2 and CCR6+ ILC2 subsets, were significantly lower compared to unstimulated conditions. Additionally, IL-10+ ILC1 levels were elevated. The ratios of IL-10+ ILC1/ILC1, c-Kit+ ILC2/c-Kit- ILC2, and CCR6+ ILC2/ILC2 were associated with the progression index (PI) in RRMS patients.
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页数：11
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