Thiochromenes and thiochromanes: a comprehensive review of their diverse biological activities and structure-activity relationship (SAR) insights

被引:0
作者
Jatin, Solai
Murugappan, Solai [1 ]
Kirad, Shivani [1 ]
Ala, Chandu [1 ]
Kuthe, Pranali Vijaykumar [1 ]
Kondapalli, Chandra Sekhar Venkata Gowri [2 ]
Sankaranarayanan, Murugesan [1 ]
机构
[1] Birla Inst Technol & Sci Pilani, Dept Pharm, Med Chem Res Lab, Pilani Campus,Vidya Vihar, Pilani 333031, Rajasthan, India
[2] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus,Jawahar Nagar, Hyderabad 500078, Telangana, India
来源
RSC MEDICINAL CHEMISTRY | 2025年
关键词
ANTIMALARIAL ACTIVITY; DERIVATIVES; SULFUR; INHIBITORS; IDENTIFICATION; ANTIBACTERIAL; DESIGN; POTENT; SCAFFOLDS;
D O I
10.1039/d4md00995a
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Thiochromene and thiochromane scaffolds, sulfur containing heterocycles, have gained significant attention in medicinal chemistry due to their diverse pharmacological activities. This review provides a comprehensive analysis of their antibacterial, antifungal, antiviral, anti-parasitic, and anticancer properties, emphasizing their therapeutic potential. SAR studies highlight key molecular modifications such as electron withdrawing substituents, sulfur oxidation, and tailored ring substitutions that enhance bioactivity, potency, and target specificity. Mechanistic insights reveal their ability to inhibit microbial enzymes, disrupt cellular pathways, and modulate key biological targets. By summarizing recent advancements, this review underscores the potential of thiochromene and thiochromane based therapeutics and encourages further research to address existing limitations and enhance their drug development prospects.
引用
收藏
页数:28
相关论文
共 50 条
  • [31] O-Glycoside quercetin derivatives: Biological activities, mechanisms of action, and structure-activity relationship for drug design, a review
    Alizadeh, Seyedeh Roya
    Ebrahimzadeh, Mohammad Ali
    [J]. PHYTOTHERAPY RESEARCH, 2022, 36 (02) : 778 - 807
  • [32] Synthesis, biological activities, and structure-activity relationships of Morita-Baylis-Hillman adducts: An update
    Devi, Nisha
    Pathania, Arun Singh
    Singh, Virender
    Sharma, Shubham
    [J]. ARCHIV DER PHARMAZIE, 2024, 357 (10)
  • [33] Isatin containing heterocycles for different biological activities: Analysis of structure activity relationship
    Nath, Rajarshi
    Pathania, Shelly
    Grover, Gourav
    Akhtar, Md Jawaid
    [J]. JOURNAL OF MOLECULAR STRUCTURE, 2020, 1222
  • [34] The significance of N-methylpicolinamides in the development of anticancer therapeutics: Synthesis and structure-activity relationship (SAR) studies
    Moku, Balakrishna
    Ravindar, Lekkala
    Rakesh, K. P.
    Qin, Hua-Li
    [J]. BIOORGANIC CHEMISTRY, 2019, 86 : 513 - 537
  • [35] An appraisal of anti-mycobacterial activity with structure-activity relationship of piperazine and its analogues: A review
    Girase, Pankaj S.
    Dhawan, Sanjeev
    Kumar, Vishal
    Shinde, Suraj R.
    Palkar, Mahesh B.
    Karpoormath, Rajshekhar
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 210
  • [36] Antibacterial activities of sulfonyl or sulfonamide containing heterocyclic derivatives and its structure-activity relationships (SAR) studies: A critical review
    Verma, Santosh Kumar
    Verma, Rameshwari
    Xue, Fan
    Thakur, Piyush Kumar
    Girish, Y. R.
    Rakesh, K. P.
    [J]. BIOORGANIC CHEMISTRY, 2020, 105
  • [37] Synthesis, Structure-Activity Relationship (SAR) Studies on some 4-Aryl-4H-chromenes and Relationship between Lipophilicity and Antitumor Activity
    El-Agrody, Ahmed M.
    Khattab, Essam Shawky A. E. H.
    Fouda, Ahmed M.
    [J]. LETTERS IN DRUG DESIGN & DISCOVERY, 2014, 11 (10) : 1167 - 1176
  • [38] Radical scavenging and anti-inflammatory activities of (hetero) arylethenesulfonyl fluorides: Synthesis and structure-activity relationship (SAR) and QSAR studies
    Jiang, Ying
    Rakesh, K. P.
    Alharbi, Njud S.
    Vivek, H. K.
    Manukumar, H. M.
    Mohammed, Y. H. E.
    Qin, Hua-Li
    [J]. BIOORGANIC CHEMISTRY, 2019, 89
  • [39] Structure-activity relationship of hybrids of Cinchona alkaloids and bile acids with in vitro antiplasmodial and antitrypanosomal activities
    Leverrier, Aurelie
    Bero, Joanne
    Cabrera, Julian
    Frederich, Michel
    Quetin-Leclercq, Joelle
    Palermo, Jorge A.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 100 : 10 - 17
  • [40] New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011-2021) focussing on structure-activity relationship (SAR) and docking insights
    Elkamhawy, Ahmed
    Ali, Eslam M. H.
    Lee, Kyeong
    [J]. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 1574 - 1602