Thiochromenes and thiochromanes: a comprehensive review of their diverse biological activities and structure-activity relationship (SAR) insights

被引：0
作者：
Jatin, Solai
Murugappan, Solai [1 ]
Kirad, Shivani [1 ]
Ala, Chandu [1 ]
Kuthe, Pranali Vijaykumar [1 ]
Kondapalli, Chandra Sekhar Venkata Gowri [2 ]
Sankaranarayanan, Murugesan [1 ]
机构：
[1] Birla Inst Technol & Sci Pilani, Dept Pharm, Med Chem Res Lab, Pilani Campus,Vidya Vihar, Pilani 333031, Rajasthan, India
[2] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad Campus,Jawahar Nagar, Hyderabad 500078, Telangana, India
来源：
RSC MEDICINAL CHEMISTRY | 2025年
关键词：
ANTIMALARIAL ACTIVITY; DERIVATIVES; SULFUR; INHIBITORS; IDENTIFICATION; ANTIBACTERIAL; DESIGN; POTENT; SCAFFOLDS;
D O I：
10.1039/d4md00995a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thiochromene and thiochromane scaffolds, sulfur containing heterocycles, have gained significant attention in medicinal chemistry due to their diverse pharmacological activities. This review provides a comprehensive analysis of their antibacterial, antifungal, antiviral, anti-parasitic, and anticancer properties, emphasizing their therapeutic potential. SAR studies highlight key molecular modifications such as electron withdrawing substituents, sulfur oxidation, and tailored ring substitutions that enhance bioactivity, potency, and target specificity. Mechanistic insights reveal their ability to inhibit microbial enzymes, disrupt cellular pathways, and modulate key biological targets. By summarizing recent advancements, this review underscores the potential of thiochromene and thiochromane based therapeutics and encourages further research to address existing limitations and enhance their drug development prospects.
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页数：28
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