Current Operating Procedure (COP) for Bleomycin ElectroScleroTherapy (BEST) of low-flow vascular malformations

被引：7

作者：

Muir, Tobian ^{[1
]}

Wohlgemuth, Walter A. ^{[2
]}

Cemazar, Maja ^{[3
,4
]}

Bertino, Giulia ^{[5
]}

Groselj, Ales ^{[6
,7
]}

Ratnam, Lakshmi A. ^{[8
,9
]}

Mccafferty, Ian ^{[10
]}

Wildgruber, Moritz ^{[11
,12
]}

Gebauer, Bernhard ^{[13
]}

de Terlizzi, Francesca ^{[14
]}

Zanasi, Alessandro ^{[14
]}

Sersa, Gregor ^{[3
,15
]}

机构：

[1] South Tees NHS Fdn Trust, Middlesbrough TS4 3BW, England

[2] Martin Luther Univ Halle Wittenberg, Clin & Policlin Radiol, Halle, Saale, Germany

[3] Inst Oncol Ljubljana, Dept Expt Oncol, Zaloska 2, Ljubljana SI-1000, Slovenia

[4] Univ Primorska, Fac Hlth Sci, Isola, Slovenia

[5] Univ Pavia, Policlin San Matteo Fdn, Ist Ricovero & Cura Carattere Sci IRCCS, Policlin San Matteo, I-27100 Pavia, Italy

[6] Univ Med Ctr, Univ Dept Otorhinolaryngol & Cervicofacial Surg, Ljubljana, Slovenia

[7] Univ Ljubljana, Fac Med, Ljubljana, Slovenia

[8] St Georges Univ Hosp NHS Fdn Trust, London, England

[9] City St Georges Univ London, Sch Hlth & Med Sci, London, England

[10] Birmingham Womens & Childrens Hosp NHS Fdn Trust, Birmingham, England

[11] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, Munich, Germany

[12] Ludwig Maximilians Univ Munchen, Univ Hosp, Interdisziplinares Zentrum Gefassanomalien IZGA, Munich, Germany

[13] Charite Univ Med Berlin, Berlin, Germany

[14] IGEA SpA, Clin Biophys Lab, Modena, Italy

[15] Univ Ljubljana, Fac Hlth Sci, Ljubljana, Slovenia

来源：

RADIOLOGY AND ONCOLOGY | 2024年 / 58卷 / 04期

关键词：

low-flow vascular malformations; bleomycin sclerotherapy; bleomycin electrosclerotherapy; BEST; ELECTROCHEMOTHERAPY; SCLEROTHERAPY; MECHANISM; CELLS;

D O I：

10.2478/raon-2024-0061

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Bleomycin ElectroScleroTherapy (BEST) is a new approach in the treatment of vascular malformations. After bleomycin is administered to the malformation, electric pulses are applied to the target area to enhance the effectiveness of bleomycin. The mode of action is comparable to the effect of electrochemotherapy on tumour vasculature. For the wider and safer use of BEST in the clinical treatment of low-flow vascular malformations, this Current Operating Procedure (COP) is being prepared. It is a proposal for the clinical standardisation of BEST using the Cliniporator (R) as the electrical pulse generator with its associated electrodes. The electrical parameters considered in this protocol are those validated by the European Standard Operating Procedures for Electrochemotherapy (ESOPE) with the Cliniporator (R).Conclusions General requirements are proposed, and, depending on the type of lesion, local skills and the availability of radiological equipment, two technical approaches of BEST are described based on ultrasound guided intervention or combined ultrasound and fluoroscopic guided intervention.

引用

页码：469 / 479

页数：11

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