Molecular mechanisms and clinical impact of biologic therapies in severe asthma

被引：3

作者：

Tashiro, Hiroki ^{[1
]}

Kuwahara, Yuki ^{[1
]}

Kurihara, Yuki ^{[1
]}

Takahashi, Koichiro ^{[1
]}

机构：

[1] Saga Univ, Fac Med, Dept Internal Med, Div Hematol Resp Med & Oncol, 5-1-1 Nabeshima, Saga, Saga 8498501, Japan

来源：

RESPIRATORY INVESTIGATION | 2025年 / 63卷 / 01期

关键词：

Asthma; Therapy; Biologics; Mechanisms; THYMIC STROMAL LYMPHOPOIETIN; INNATE LYMPHOID-CELLS; QUALITY-OF-LIFE; FC-EPSILON-RI; INDUCED AIRWAY INFLAMMATION; HUMAN EPITHELIAL-CELLS; TO-SEVERE ASTHMA; IGM(+) B-CELLS; DOUBLE-BLIND; OX40; LIGAND;

D O I：

10.1016/j.resinv.2024.11.015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Severe asthma is a critical condition for patients with asthma, characterized by frequent exacerbations, decreased pulmonary function, and unstable symptoms related to asthma. Consequently, the administration of systemic corticosteroids, which cause secondary damage because of their adverse effects, is considered. Recently, several types of molecular-targeted biological therapies have become available for patients with severe asthma, and they have a capacity to improve the pathophysiology of severe asthma. However, several clinical reports indicate that the effects differ depending on the biological targets of asthma in individual patients. In this review, the molecular mechanisms and clinical impact of biologic therapies in severe asthma are described. In addition, molecules targeted by possible future biologics are also addressed. Better understanding of the mechanistic basis for the role of biologics in severe asthma could lead to new therapeutic options for these patients.

引用

页码：50 / 60

页数：11

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