Body mass index, regional adipose deposition, and clinical outcomes in non-ischaemic dilated cardiomyopathy: a prospective cohort study

被引：0

作者：

Huang, Chuan ^{[1
]}

Li, Yangjie ^{[1
]}

Xu, Yuanwei ^{[1
]}

Zhou, Yaqiong ^{[1
]}

Li, Weihao ^{[1
]}

Guo, Jiajun ^{[1
]}

Wan, Ke ^{[2
]}

Wang, Jie ^{[1
]}

Xu, Ziqian ^{[1
]}

Zhang, Qing ^{[1
]}

Han, Yuchi ^{[3
]}

Sun, Jiayu ^{[4
]}

Chen, Yucheng ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Cardiol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China

[3] Ohio State Univ, Cardiovasc Div, Wexner Med Ctr, Columbus, OH 43210 USA

[4] Sichuan Univ, West China Hosp, Dept Radiol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China

来源：

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY | 2025年

关键词：

Body mass index; Regional adipose deposition; Dilated cardiomyopathy; Clinical outcomes; Cohort study; HEART-FAILURE; OBESITY PARADOX; OVERWEIGHT; TISSUE;

D O I：

10.1093/eurjpc/zwaf028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims This study aims to assess the relationship between body mass index (BMI), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), epicardial adipose tissue (EAT), pericardial adipose tissue (PAT), and clinical outcomes in dilated cardiomyopathy (DCM) patients. Methods and results Non-ischaemic DCM patients were prospectively enrolled. Regional adipose tissue, cardiac function, and myocardial tissue characteristics were measured by cardiac magnetic resonance. The primary endpoint included all-cause mortality and heart transplantation (HTX). This study enrolled 1042 DCM patients (68% men, mean age 48 +/- 15 years, mean BMI 23.9 +/- 4.0 kg/m2). Underweight patients were more frequently women and had lower blood pressure, worse New York Heart Association class, reduced biventricular ejection fraction, and higher native T1 and extracellular volume fraction value. Similarly, reduced regional adipose tissue was associated with adverse heart remodelling, worse cardiac function, and higher diffuse myocardial fibrosis. After a median follow-up of 41 months, primary endpoint occurred in 237 patients. Body mass index [hazard ratio (HR): 0.94, 95% confidence interval (CI): 0.90-0.98, P = 0.006], VAT thickness (per 1 mm: HR 0.94, 95% CI: 0.91-0.97, P < 0.001), and EAT volume (per 1 mL: HR 0.96, 95% CI: 0.95-0.97, P < 0.001) were independent predictors of primary endpoint. Epicardial adipose tissue volume showed the highest predictive value for heart failure death/HTX (C-index: 0.70). Body mass index was the best predictor of arrhythmia endpoint (C-index: 0.64). Conclusion Lower BMI and thinner regional adipose tissue represented the worse clinical phenotype and adverse remodelling and were associated with worse clinical outcomes in patients with DCM.

引用

页数：11