Natural products and derivatives as Japanese encephalitis virus antivirals

被引：3

作者：

Mi, Yunqi ^{[1
]}

Guo, Yan ^{[2
]}

Luo, Xuliang ^{[3
]}

Bai, Yang ^{[1
]}

Chen, Haonan ^{[1
]}

Wang, Meihua ^{[4
]}

Wang, Yang ^{[1
]}

Guo, Jiao ^{[1
]}

机构：

[1] Xian Med Univ, Sch Basic Med, Xian Key Lab Pathogen Microorganism & Tumor Immun, Xian 710021, Peoples R China

[2] Xian Univ Posts & Telecommun, Sch Modern Post, Xian 710061, Peoples R China

[3] Huazhong Agr Univ, Coll Anim Sci & Technol, Coll Vet Med, Wuhan 430070, Peoples R China

[4] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Peoples R China

来源：

PATHOGENS AND DISEASE | 2024年 / 82卷

基金：

美国国家科学基金会;

关键词：

JEV; bioactive natural products; antiviral drug development; DENGUE VIRUS; CRYSTAL-STRUCTURE; NONSTRUCTURAL PROTEINS; CONFORMATIONAL-CHANGES; NEUTRALIZING-ANTIBODY; HELICASE ACTIVITY; ASTRAGALI RADIX; NS3; HELICASE; ALOE-EMODIN; DOMAIN-III;

D O I：

10.1093/femspd/ftae022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Japanese encephalitis virus (JEV) causes acute Japanese encephalitis (JE) in humans and reproductive disorders in pigs. There are similar to 68 000 cases of JE worldwide each year, with similar to 13 600-20 400 deaths. JE infections have a fatality rate of one-third, and half of the survivors experience permanent neurological sequelae. The disease is prevalent throughout the Asia-Pacific region and has the potential to spread globally. JEV poses a serious threat to human life and health, and vaccination is currently the only strategy for long-term sustainable protection against JEV infection. However, licensed JEV vaccines are not effective against all strains of JEV. To date, there are no drugs approved for clinical use, and the development of anti-JEV drugs is urgently needed. Natural products are characterized by a wide range of sources, unique structures, and low prices, and this paper provides an overview of the research and development of anti-JEV bioactive natural products.

引用

页数：15

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