Herbal extract ( Cervus elaphus Linnaeus, Angelica gigas Nakai, and Astragalus membranaceus Bunge) ameliorates chronic fatigue: A randomized, placebo-controlled, double-blind trial

Background: Chronic fatigue syndrome (CFS) reduces the health-related quality of life in the working-age pop ulation, however, studies have rarely investigated this group. A misture of Cervus elaphus Linnaesis, Angelica gigas Nakal, Astragalus membranacess Bunge (CAA) may effective anti-fatigue supplement. However, clinical trials have explored the a anti-fatigue effects of herbal medicines in human participants. Therefore, this study aimed to investigate the effects of the CAA herbal complex on muscle fatigue and endurance capacity in a randomized, placebo-controlled, double-blind trial. Method: la 8-wock trial, 80 patients with chronic fatigue symptoms randonly assigned to the CAA (43.5 +/- 1.2 years) or placcho group (41.8 +/- 1.3 years). Fatigue and candinerspicatury endurance at baseline, interim, and post-intervention. Fatigue-related blood biomacker ausessed before of the intervention Results: A significant improvement in overall fatigue scures observed on the fatigue severity scale (-0.038), multidimensional fatigue inventory (p=0.037), and 24-hour visual analog scale (p=0.002) is the CAA group compared to those in the placeho group. Fatigue improvestment sabserved in the CAA group, as well as physi ological variables, such as increased maximal exercise time to exhaustion (p=0.003), distance until exhaustion -0.003), and maximun oxygen consumption (p=0.039) Conclusion: CAA positively and significantly affected fatigue and cardiorespiratory endurance in patients with chronic fatigue, suggesting the potemiat of herbal supplements for treating chronic fatigue. Trial reglaration Clinical Research Infomation Service (CRIS, http://eris.all.gs/KCT0005613.