Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study

被引：0

作者：

Thomson, Lindsay M. ^{[1
]}

Niemiec, Sierra ^{[2
]}

Mancuso, Christopher A. ^{[2
]}

Khailova, Ludmila ^{[1
]}

Ali, Eiman ^{[1
]}

Syed, Aneesa ^{[3
]}

Wolfe, Kelly R. ^{[1
]}

Zakrzewski, Jack ^{[3
]}

Stone, Matthew ^{[4
]}

Hyslop, Robert ^{[5
]}

Frank, Benjamin S. ^{[1
]}

Davidson, Jesse A. ^{[1
]}

机构：

[1] Univ Colorado Anschutz Med Campus, Dept Pediat, Aurora, CO 80045 USA

[2] Univ Colorado Anschutz Med Campus, Dept Biostat & Informat, Aurora, CO USA

[3] Childrens Hosp Colorado, Dept Pathol & Lab Med, Aurora, CO USA

[4] Univ Colorado Anschutz Med Campus, Deparment Surg, Aurora, CO USA

[5] Childrens Hosp Colorado, Heart Inst, Aurora, CO USA

来源：

JOURNAL OF PEDIATRICS | 2025年 / 276卷

基金：

美国国家卫生研究院;

关键词：

cardiac surgery; cardiopulmonary bypass; ECMO; erythropoietin; protein biomarkers; proteomics;

D O I：

10.1016/j.jpeds.2024.114322

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.

引用

页数：5

共 8 条

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