Inhalation Anesthetics Play a Janus-Faced Role in Self-Renewal and Differentiation of Stem Cells

被引:0
作者
Hao, Xiaotong [1 ]
Li, Yuan [1 ]
Gao, Hairong [1 ]
Wang, Zhilin [2 ]
Fang, Bo [1 ]
机构
[1] China Med Univ, Hosp 1, Dept Anesthesiol, Shenyang 110001, Peoples R China
[2] China Med Univ, Hosp 1, Dept Pain Med, Shenyang 110001, Peoples R China
基金
中国国家自然科学基金;
关键词
inhaled anesthetics; stem cells; self-renewal; proliferation; differentiation; TOTAL INTRAVENOUS ANESTHESIA; SEVOFLURANE ANESTHESIA; E-CADHERIN; NEURAL DIFFERENTIATION; SIGNALING PATHWAY; NANOG EXPRESSION; PROGENITOR CELLS; PROLIFERATION; EXPOSURE; PROMOTES;
D O I
10.3390/biom14091167
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Inhalation anesthesia stands as a pivotal modality within clinical anesthesia practices. Beyond its primary anesthetic effects, inhaled anesthetics have non-anesthetic effects, exerting bidirectional influences on the physiological state of the body and disease progression. These effects encompass impaired cognitive function, inhibition of embryonic development, influence on tumor progression, and so forth. For many years, inhaled anesthetics were viewed as inhibitors of stem cell fate regulation. However, there is now a growing appreciation that inhaled anesthetics promote stem cell biological functions and thus are now regarded as a double-edged sword affecting stem cell fate. In this review, the effects of inhaled anesthetics on self-renewal and differentiation of neural stem cells (NSCs), embryonic stem cells (ESCs), and cancer stem cells (CSCs) were summarized. The mechanisms of inhaled anesthetics involving cell cycle, metabolism, stemness, and niche of stem cells were also discussed. A comprehensive understanding of these effects will enhance our comprehension of how inhaled anesthetics impact the human body, thus promising breakthroughs in the development of novel strategies for innovative stem cell therapy approaches.
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页数:20
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