Acute Myeloid Leukemia in Older Patients: From New Biological Insights to Targeted Therapies

被引：3

作者：

Niscola, Pasquale ^{[1
]}

Gianfelici, Valentina ^{[1
]}

Catalano, Gianfranco ^{[2
]}

Giovannini, Marco ^{[1
]}

Mazzone, Carla ^{[1
]}

Noguera, Nelida Ines ^{[2
,3
]}

de Fabritiis, Paolo ^{[1
,2
]}

机构：

[1] S Eugenio Hosp ASL Roma 2, Hematol Unit, I-00144 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy

[3] IRCCS, St Lucia Fdn, Neurooncoemtol Units, I-00143 Rome, Italy

来源：

CURRENT ONCOLOGY | 2024年 / 31卷 / 11期

关键词：

genomic profiling; targeted therapies; hypomethylating agents; venetoclax-based combinations; intensive chemotherapy; transplantation clinical trials; supportive care; quality of life; HEALTH-ORGANIZATION CLASSIFICATION; MEASURABLE RESIDUAL DISEASE; VENETOCLAX-BASED THERAPY; GILTERITINIB; AZACITIDINE; METABOLISM; CHEMOTHERAPY; NEOPLASMS; EVOLUTION; CRITERIA;

D O I：

10.3390/curroncol31110490

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) is a heterogeneous blood-related neoplasm that predominantly afflicts older adults with a poor prognosis due to their physical condition and the presence of medical accompanying comorbidities, adverse biological disease features, and suitability for induction intensive chemotherapy and allogenic stem cells transplantation. Recent research into the molecular and biological factors contributing to disease development and progression has led to significant advancements in treatment approaches for older patients with AML. This review article discusses the latest biological and therapeutic developments that are transforming the management of AML in older adults.

引用

页码：6632 / 6658

页数：27

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