Ionic Liquid Aided [11C]CO Fixation for Synthesis of 11C-carbonyls

被引：0

作者：

Lindberg, Anton ^{[1
]}

Mokhatarinori, Narges ^{[2
]}

Yang, Zhenzhen ^{[2
]}

Dai, Sheng ^{[2
]}

Popovs, Ilja ^{[2
]}

Vasdev, Neil ^{[3
]}

机构：

[1] CAMH, Azrieli Ctr Neuroradiochem, Brain Hlth Imaging Ctr, 250 Coll St, Toronto, ON M5T 1R8, Canada

[2] Oak Ridge Natl Lab, Chem Sci Div, Oak Ridge, TN USA

[3] Univ Toronto, CAMH, Azrieli Ctr Neuroradiochem, Brain Hlth Imaging Ctr,Dept Psychiat, 250 Coll St, Toronto, ON M5T 1R8, Canada

来源：

CHEMISTRYOPEN | 2025年 / 14卷 / 07期

基金：

加拿大创新基金会;

关键词：

Ionic liquid; Carbon-11; Radiochemistry; Positron emission tomography;

D O I：

10.1002/open.202400410

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tributyl(ethyl)phosphonium oxopentenolate ([P4442][Pen]) is an ionic liquid developed to capture CO and has shown ability to catalyze carbonylation reactions in organic chemistry. Carbon-11 (11C, t1/2=20.4 min) labeled CO is a highly versatile building block for the synthesis of positron emission tomography (PET) radiotracers that are applied for medical imaging. The use of [11C]CO is limited by its low solubility in organic solvents. Herein, we report a proof-of-concept study evaluating a new method to prepare 11C-labeled amides, ureas and carbamates via reaction of [11C]CO in [P4442][Pen] and applied for fully automated radiosyntheses of Bruton's tyrosine kinase inhibitors, [11C]evobrutinib and [11C]ibrutinib.

引用

页数：4

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