Geographic Atrophy Secondary to Subclinical Angioid Streaks in Age-Related Macular Degeneration: Progression of the Disease at 2-Year Follow-Up

被引：0

作者：

Riccardo Sacconi ^{[1
]}

Simone Marra ^{[2
]}

Elena Spada ^{[1
]}

Federico Beretta ^{[2
]}

Matteo Menna ^{[1
]}

Stefano Menecozzi ^{[2
]}

Francesco Bandello ^{[1
]}

Giuseppe Querques ^{[2
]}

机构：

[1] School of Medicine, Vita-Salute San Raffaele University, Milan

[2] Division of Head and Neck, Ophthalmology Unit, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan

来源：

Ophthalmology and Therapy | 2025年 / 14卷 / 5期

关键词：

Age-related macular degeneration; Angioid streaks; Biomarker; Geographic atrophy; Multimodal imaging; OCT; Reticular pseudodrusen; Subclinical angioid streaks;

D O I：

10.1007/s40123-025-01111-4

中图分类号：

学科分类号：

摘要：

Introduction: The purpose of the study is to characterize the rate of progression of geographic atrophy (GA) areas in patients with age-related macular degeneration (AMD) with subclinical angioid streaks (AS), compared to patients with AMD without subclinical AS. Methods: This is a retrospective, longitudinal, case–control study. Among a cohort of patients with AMD, we selected patients with GA with subclinical AS and followed them for a 2-year follow-up. An age- and sex-matched control group with GA secondary to AMD without subclinical AS was selected. Demographics and differences in the GA progression between the two groups were analyzed. Results: Among 60 eyes of 60 patients affected by GA secondary to AMD, 20 eyes of 20 patients (mean age 82 ± 5 years old) were included in the subclinical AS group, whereas 40 eyes of 40 patients (mean age 79 ± 6 years old, p = 0.077) were in the control group. All 20 eyes of subclinical AS group showed reticular pseudodrusen at the baseline compared to 73% of patients without AS (p = 0.002). In the subclinical AS group, 90% of eyes showed peripapillary atrophy in comparison to 63% in the control group (p = 0.026). Subclinical AS eyes showed a significantly lower subfoveal choroidal thickness in comparison to the control group (124 ± 60 μm vs. 161 ± 84 μm, respectively, p = 0.043). At 2-year follow-up, the rate of progression was higher in the patients with subclinical AS; the yearly growth rate was 0.41 ± 0.17 mm/year after the square root transformation in the subclinical AS group, in comparison to 0.32 ± 0.14 mm/year in the control group (p = 0.017). Conclusions: Patients with subclinical AS showed a more aggressive phenotype of GA in comparison to AMD patients without subclinical AS, characterized by a higher rate of progression of GA areas during a 2-year follow-up. © The Author(s) 2025.

引用

页码：911 / 922

页数：11

共 28 条

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