Is using inhaled corticosteroid effective against COVID-19 pneumonia severity and mortality?

被引：0

作者：

Kilic, Hatice ^{[1
]}

Arguder, Emine ^{[1
]}

Civak, Musa ^{[2
]}

Gemcioglu, Emin ^{[2
]}

Kaya Kalem, Ayse ^{[3
]}

Hasanoglu, Imran ^{[3
]}

Kayaaslan, Bircan ^{[3
]}

Gunay, Sibel ^{[4
]}

Akpinar, Esmehan ^{[4
]}

Hezer, Habibe ^{[4
]}

Seref Parlak, Ebru Sengul ^{[4
]}

Sadi Aykan, Filiz ^{[4
]}

Kocaman, Yasin ^{[4
]}

Unsay Metan, Esra ^{[4
]}

Er, Mukremin ^{[4
]}

Dalkiran, Aynil ^{[4
]}

Celenk Erguden, Hulya ^{[4
]}

Hancioglu, Zeynep ^{[4
]}

Altin, Emre ^{[4
]}

Ceylan, Eren ^{[4
]}

Eser, Fatma ^{[3
]}

Altunsoy Aypak, Adalet ^{[5
]}

Akinci, Esragul ^{[5
]}

Karaahmetoglu, Selma ^{[2
]}

Asfuroglu Kalkan, Emra ^{[2
]}

Inan, Osman ^{[2
]}

Yilmaz, Abdurrezzak ^{[2
]}

Yuksel Guler, Bagdagul ^{[2
]}

Copuroglu, Esra ^{[2
]}

Ozkocak Turan, Isil ^{[6
]}

Demir, Emre ^{[7
]}

Hayme, Serhat ^{[8
]}

Gokmen, Derya ^{[8
]}

Surel, Aziz Ahmet ^{[9
]}

Unsal, Ebru ^{[1
]}

Hasanoglu, Hatice Canan ^{[1
]}

Ates, Ihsan ^{[2
]}

Guner, Rahmet ^{[3
]}

Karalezli, Aysegul ^{[1
]}

机构：

[1] Ankara Yildirim Beyazit Univ, Dept Pulm Dis, Fac Med, Ankara, Turkiye

[2] Ankara City Hosp, Clin Internal Med Dis, Ankara, Turkiye

[3] Ankara Yildirim Beyazit Univ, Fac Med, Dept Infect Dis, Ankara, Turkiye

[4] Ankara City Hosp, Clin Pulm Dis, Ankara, Turkiye

[5] Ankara City Hosp, Clin Infect Dis, Ankara, Turkiye

[6] Ankara City Hosp, Clin Anesthesiol, Ankara, Turkiye

[7] Hitit Univ, Fac Med, Dept Biostat, Corum, Turkiye

[8] Ankara Univ, Fac Med, Dept Biostat, Ankara, Turkiye

[9] Ankara City Hosp, Clin Gen Surg, Ankara, Turkiye

来源：

TUBERKULOZ VE TORAKS-TUBERCULOSIS AND THORAX | 2024年 / 72卷 / 03期

关键词：

COVID-19; asthma; COPD; inhaled corticosteroid; mortality; OBSTRUCTIVE PULMONARY-DISEASE; ASTHMA; RISK; INFECTION; OUTCOMES;

D O I：

10.5578/tt.202403934

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction: It is known that the use of inhaled corticosteroids increases the incidence of pneumonia in patients followed up with the diagnosis of chronic asthma and chronic obstructive pulmonary disease (COPD). This study aimed to investigate the contribution of inhaled steroid use to pneumonia severity and mortality in cases with COVID-19 pneumonia. Materials and Methods: The study is a retrospective, observational study. Among the cases admitted to the pandemic clinic, patients diagnosed with COVID-19 pneumonia were included. The plan was to compare cases who received and did not receive inhaled corticosteroids in terms of pneumonia severity and mortality. In order to define risk factors for mortality, univariate and multivariable negative binomial regression analyses were performed. Results: In our study, it was observed that n= 540 (75%) cases did not receive inhaled corticosteroids (group 1), and 180 (25%) cases used inhaled corti costeroids (group 2). Group 1 and group 2 cases were compared in terms of pneumonia severity with no significant difference between the two groups (p= 0.11). Then, risk factors affecting mortality in all cases were examined with univariate analyses. Increasing age, applying mechanical ventilation, having severe pneumonia, having interstitial lung disease, and applying prone position were found to be statistically significant factors in mortality (p< 0.05). Conclusion: In conclusion, in our study, it was observed that the use of inhaled corticosteroids did not increase the severity of pneumonia and mortality. It was thought that the treatment they received could be continued when the patients treated with inhaled corticosteroids due to asthma and COPD had COVID-19 pneumonia.

引用

页数：66

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