Rapid Assembly of 1,3-Dicarbonyl Fused 5-phenyl-1-Azabicyclo[3.1.0]hexanes and Their Cytotoxic Activities

被引：1

作者：

Pal, Biral Kanti ^{[1
]}

Sahoo, Kanchanbala ^{[1
]}

Dey, Sourav ^{[2
]}

Bharathavikru, Ruthrotha Selvi ^{[2
]}

Thirupathi, Barla ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Berhampur, Dept Chem Sci, Transit Campus, Berhampur 760010, Odisha, India

[2] Indian Inst Sci Educ & Res Berhampur, Dept Biol Sci, Transit Campus, Berhampur 760010, Odisha, India

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 03期

关键词：

VINYL AZIDES;

D O I：

10.1021/acs.orglett.4c04394

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of complex, multiring, spirocyclic, 1,3-dicarbonyl fused, and highly functionalized 5-phenyl-1-azabicyclo[3.1.0]hexanes (ABCH) has been achieved by an intermolecular reaction of 2-(2 '-ketoalkyl)-1,3-indandiones or alpha,gamma-diketo esters with (1-azidovinyl)benzenes under transition metal-free conditions. The reaction proceeds in a highly diastereoselective manner with a wide range of functional groups and provides moderate to good yields. Additionally, we have studied the preliminary biological activities of a few synthetic compounds against HeLa and triple-negative breast cancer (TNBC) cell lines.

引用

页码：761 / 766

页数：6