From Bench to Bedside: Translating Cellular Rejuvenation Therapies into Clinical Applications

被引：0
作者：
Saliev, Timur [1 ]
Singh, Prim B. [2 ]
机构：
[1] SD Asfendiyarov Kazakh Natl Med Univ, Tole Bi St 94, Alma Ata 050000, Kazakhstan
[2] Nazarbayev Univ, Sch Med, Astana 010000, Kazakhstan
来源：
CELLS | 2024年 / 13卷 / 24期
关键词：
rejuvenation; senolytics; CRISPR; induced pluripotent stem cells; mesenchymal stem cells; ARTIFICIAL-INTELLIGENCE; INFLAMMATION; SENESCENCE; AGE;
D O I：
10.3390/cells13242052
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular rejuvenation therapies represent a transformative frontier in addressing age-related decline and extending human health span. By targeting fundamental hallmarks of aging-such as genomic instability, epigenetic alterations, mitochondrial dysfunction, and cellular senescence-these therapies aim to restore youthful functionality to cells and tissues, offering new hope for treating degenerative diseases. Recent advancements have showcased a range of strategies, including epigenetic reprogramming, senolytic interventions, mitochondrial restoration, stem cell-based approaches, and gene-editing technologies like CRISPR. Each modality has demonstrated substantial potential in preclinical models and is now being cautiously explored in early-stage clinical trials. However, translating these therapies from the laboratory to clinical practice presents unique challenges: safety concerns, delivery precision, complex regulatory requirements, ethical considerations, and high costs impede widespread adoption. This review examines the current landscape of cellular rejuvenation, highlighting key advancements, potential risks, and the strategies needed to overcome these hurdles.
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页数：24
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