Perianal leiomyosarcoma as a rare sequela of rectal cancer radiotherapy: a case report

被引:0
作者
Chen, Chaopeng [1 ]
Cai, Wenping [2 ]
Li, Yujiao [3 ]
Ren, Junqi [3 ]
Xu, Zhibin [4 ]
Pang, Lijuan [2 ]
Dai, Weiping [1 ]
机构
[1] Cent Hosp Guangdong Prov Nongken, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[2] Guangdong Med Univ, Cent Peoples Hosp Zhanjiang, Zhanjiang Cent Hosp, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[3] Guangdong Med Univ, Affiliated Hosp 2, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[4] Guangzhou Med Univ, Dept Organ Transplantat, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
radiation-induced sarcoma (RIS); rectal adenocarcinoma; leiomyosarcoma; neoadjuvant chemoradiotherapy; pathological diagnosis;
D O I
10.3389/fonc.2024.1474536
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation-induced sarcomas (RIS) are iatrogenic malignancies that arise following high-dose radiotherapy, posing a significant clinical challenge due to their poor prognosis and resistance to conventional treatments. The incidence of RIS is increasing with advancements in radiotherapy techniques. This report presents a case of a 71-year-old male diagnosed with stage III rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and curative surgery. Three years postoperatively, he developed a low-grade radiation-induced leiomyosarcoma in the perianal region. Histopathological examination confirmed a spindle cell neoplasm with notable immunohistochemical markers. RIS often presents as aggressive high-grade tumors resistant to radiotherapy and chemotherapy, necessitating surgical resection as the primary treatment. This case underscores the importance of long-term surveillance post-radiotherapy and highlights the need for innovative therapeutic strategies, including immunotherapy. Despite being rare, RIS poses a significant risk following cancer treatment, making early detection through vigilant monitoring and advancements in therapeutic approaches crucial for improving patient outcomes.
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页数:8
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共 28 条
  • [1] Pre-existing subclones determine radioresistance in rectal cancer organoids
    Andel, Daan
    Viergever, Bas Jeroen
    Peters, Niek Alexander
    Raats, Danielle Adriana Elisabeth
    Schelven, Susanne Jolien Schenning-van
    Intven, Martijn Peter Willem
    Zandvliet, Maurice
    Hagendoorn, Jeroen
    Rinkes, Inne Hilbrand Max Borel
    Kranenburg, Onno
    [J]. CELL REPORTS, 2024, 43 (02):
  • [2] Basu I., 2012, Ann R Coll Surg Engl, V94, pe445, DOI [10.1308/003588412x13171221499469, DOI 10.1308/003588412X13171221499469]
  • [3] Hereditary bone tumors
    Baumhoer, D.
    [J]. PATHOLOGE, 2017, 38 (03): : 179 - 185
  • [4] A practical framework for the targeted use of total neoadjuvant therapy for rectal cancer
    Bhutiani, Neal
    Peacock, Oliver
    Chang, George J.
    [J]. CANCER, 2022, 128 (11) : 2064 - 2072
  • [5] The synergistic effect of radiotherapy and immunotherapy: A promising but not simple partnership
    Chajon, Enrique
    Castelli, Joel
    Marsiglia, Hugo
    De Crevoisier, Renaud
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2017, 111 : 124 - 132
  • [6] Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms
    Chen, Guangxia
    Han, Yi
    Zhang, Haihan
    Tu, Wenling
    Zhang, Shuyu
    [J]. FRONTIERS IN ONCOLOGY, 2021, 11
  • [7] Syndrome-associated soft tissue tumours
    Coffin, Cheryl M.
    Davis, Jessica L.
    Borinstein, Scott C.
    [J]. HISTOPATHOLOGY, 2014, 64 (01) : 68 - 87
  • [8] Temporary Knockdown of p53 During Focal Limb Irradiation Increases the Development of Sarcomas
    Daniel, Andrea R.
    Su, Chang
    Williams, Nerissa T.
    Li, Zhiguo
    Huang, Jianguo
    Lopez, Omar
    Luo, Lixia
    Ma, Yan
    Campos, Lorraine da Silva
    Selitsky, Sara R.
    Modliszewski, Jennifer L.
    Liu, Siyao
    Hernansaiz-Ballesteros, Rosa
    Mowery, Yvonne M.
    Cardona, Diana M.
    Lee, Chang-Lung
    Kirsch, David G.
    [J]. CANCER RESEARCH COMMUNICATIONS, 2023, 3 (12): : 2455 - 2467
  • [9] Radiation-Induced Sarcomas of the Breast: A Review of a 20-Year Single-Center Experience
    Di Lalla, Vanessa
    Tolba, Marwan
    Khosrow-Khavar, Farzin
    Baig, Ayesha
    Freeman, Carolyn
    Panet-Raymond, Valerie
    [J]. CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (04)
  • [10] Neoadjuvant short-course hyperfractionated accelerated radiotherapy (SC-HART) combined with S-1 for locally advanced rectal cancer
    Doi, Hiroshi
    Beppu, Naohito
    Odawara, Soichi
    Tanooka, Masao
    Takada, Yasuhiro
    Niwa, Yasue
    Fujiwara, Masayuki
    Kimura, Fumihiko
    Yanagi, Hidenori
    Yamanaka, Naoki
    Kamikonya, Norihiko
    Hirota, Shozo
    [J]. JOURNAL OF RADIATION RESEARCH, 2013, 54 (06) : 1118 - 1124