Molecular Mechanisms and Therapeutic Targets of Hepatitis B Virus Pre-S Mutant-Associated Hepatocellular Carcinoma Tumorigenesis

被引：0

作者：

Jeng, Long-Bin ^{[1
,2
,3
]}

Chan, Wen-Ling ^{[4
,5
]}

Teng, Chiao-Fang ^{[1
,6
,7
]}

机构：

[1] China Med Univ Hosp, Organ Transplantat Ctr, Taichung, Taiwan

[2] China Med Univ Hosp, Dept Surg, Taichung, Taiwan

[3] China Med Univ Hosp, Cell Therapy Ctr, Taichung, Taiwan

[4] China Med Univ, Coll Publ Hlth, Dept Publ Hlth, Taichung, Taiwan

[5] Asia Univ, Coll Med & Hlth Sci, Dept Healthcare Adm, Taichung, Taiwan

[6] China Med Univ, Grad Inst Biomed Sci, 91,Hsueh-Shih Rd,Northern Dist, Taichung 404, Taiwan

[7] China Med Univ, Master Program Canc Biol & Drug Discovery, Taichung, Taiwan

来源：

CANCER CONTROL | 2025年 / 32卷

关键词：

hepatocellular carcinoma; pre-S mutant; hepatitis B virus; molecular mechanism; therapeutic target; GROUND-GLASS HEPATOCYTES; ENDOPLASMIC-RETICULUM STRESS; LARGE SURFACE PROTEIN; CYCLIN-A EXPRESSION; X PROTEIN; MUTATIONS; ACTIVATION; DELETION; LIVER; HBV;

D O I：

10.1177/10732748251320492

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Despite significant progress in diagnosis and therapeutics, hepatocellular carcinoma (HCC) is still among the most commonly occurring and life-taking human cancers globally, raising an urgent need for discovering effective therapeutic targets.Purpose: Chronic hepatitis B virus (HBV) infection is a major etiological factor associated with HCC development, progression, and prognosis. Pre-S mutants are naturally occurring mutated forms of HBV large surface proteins and predict a higher risk of HCC development and recurrence. Moreover, pre-S mutants function as important HBV oncoproteins which can promote HCC tumorigenesis through initiating a variety of oncogenic signaling pathways. Targeting pre-S mutant-induced oncogenic signaling pathways displays therapeutic potential in HCC.Research Design: This review summarizes the underlying molecular mechanisms of pre-S mutant-associated HCC tumorigenesis and highlights their potential in serving as therapeutic targets for HCC.

引用

页数：7