Review article: Prevention of inflammatory bowel disease-The path forward

被引:7
作者
Bronze, Sergio [1 ,2 ,3 ]
Agrawal, Manasi [3 ]
Colombel, Jean-Frederic [3 ]
Torres, Joana [2 ,4 ,5 ]
Ungaro, Ryan C. [3 ]
机构
[1] Gastroenterol & Hepatol Dept, Unidade Local Saude Santa Maria, Lisbon, Portugal
[2] Univ Lisbon, Fac Med Lisboa, Lisbon, Portugal
[3] Icahn Sch Med Mt Sinai, Dept Med, Div Gastroenterol, New York, NY 10029 USA
[4] Hosp luz Lisboa, Div Gastroenterol, Lisbon, Portugal
[5] Hosp Beatriz Angelo, Div Gastroenterol, Loures, Portugal
关键词
CROHNS-DISEASE; MODIFYING THERAPY; RISK; RELATIVES; BIOMARKERS; DIAGNOSIS; FAMILY;
D O I
10.1111/apt.18263
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BackgroundThe possibility of preventing inflammatory bowel disease (IBD) is becoming more plausible due to advances in understanding preclinical disease and successful prevention trials in other immune-mediated diseases, such as type 1 diabetes and rheumatoid arthritis. However, before that possibility becomes reality, several efforts need to occur in parallel and in a coordinated way.AimTo propose some critical steps necessary for advancing the field of IBD prediction and prevention.MethodsWe reviewed the current literature to identify the necessary steps toward a preventive strategy for IBD.ResultsThe first step should determine the most robust predictive biomarkers and validate them across independent cohorts, creating a multidimensional predictive tool. The second step is to gain a better understanding of the preferences of first-degree relatives and people at risk for IBD, informing the implementation of screening and preventive strategies. Third, these efforts should contribute to the development of high-risk clinics and establish the necessary networks for disease prevention trials.ConclusionsAdvancing the field of IBD prediction and prevention will require a multifaceted approach, integrating biomarker discovery, understanding patient preferences, and establishing infrastructure for a collaborative network to support the practical implementation of IBD prevention strategies. The possibility of preventing inflammatory bowel disease (IBD) is becoming more plausible. In this context, we outline some critical key steps essential for advancing the field of IBD prediction and prevention.image
引用
收藏
页码:1166 / 1175
页数:10
相关论文
共 44 条
  • [1] Agrawal M., Clin Gastroenterol Hepatol
  • [2] Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes
    Bingley, Polly J.
    Wherrett, Diane K.
    Shultz, Ann
    Rafkin, Lisa E.
    Atkinson, Mark A.
    Greenbaum, Carla J.
    [J]. DIABETES CARE, 2018, 41 (04) : 653 - 661
  • [3] Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study
    Burisch, Johan
    Katsanos, Konstantinos H.
    Christodoulou, Dimitrios K.
    Barros, Luisa
    Magro, Fernando
    Pedersen, Natalia
    Kjeldsen, Jens
    Vegh, Zsuzsanna
    Lakatos, Peter L.
    Eriksson, Carl
    Halfvarson, Jonas
    Fumery, Mathurin
    Gower-Rousseau, Corinne
    Brinar, Marko
    Cukovic-Cavka, Silvija
    Nikulina, Inna
    Belousova, Elena
    Myers, Sally
    Sebastian, Shaji
    Kiudelis, Gediminas
    Kupcinskas, Limas
    Schwartz, Doron
    Odes, Selwyn
    Kaimakliotis, Ioannis P.
    Valpiani, Daniela
    D'Inca, Renata
    Salupere, Riina
    Zammit, Stefania Chetcuti
    Ellul, Pierre
    Duricova, Dana
    Bortlik, Martin
    Goldis, Adrian
    Kievit, Hendrika Adriana Linda
    Toca, Alina
    Turcan, Svetlana
    Midjord, Jongero
    Nielsen, Kari Rubek
    Andersen, Karina Winther
    Andersen, Vibeke
    Misra, Ravi
    Arebi, Naila
    Oksanen, Pia
    Collin, Pekka
    de Castro, Luisa
    Hernandez, Vicent
    Langholz, Ebbe
    Munkholm, Pia
    [J]. JOURNAL OF CROHNS & COLITIS, 2019, 13 (02) : 198 - 208
  • [4] Review article: Optimisation of biologic (monoclonal antibody) therapeutic response in inflammatory bowel disease
    Chaemsupaphan, Thanaboon
    Leong, Rupert W.
    Vande Casteele, Niels
    Seow, Cynthia H.
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2024, 60 (09) : 1234 - 1243
  • [5] Preclinical Serological Signatures are Associated With Complicated Crohn's Disease Phenotype at Diagnosis
    Choung, Rok Seon
    Petralia, Francesca
    Torres, Joana
    Ungaro, Ryan C.
    Porter, Chad
    Sato, Takahiro
    Telesco, Shannon
    Strauss, Richard S.
    Plevy, Scott
    Princen, Fred
    Riddle, Mark S.
    Murray, Joseph A.
    Colombel, Jean Frederic
    [J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2023, 21 (11) : 2928 - +
  • [6] Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial
    Cope, Andrew P.
    Jasenecova, Marianna
    Vasconcelos, Joana C.
    Filer, Andrew
    Raza, Karim
    Qureshi, Sumera
    D'Agostino, Maria Antonietta
    Mcinnes, Iain B.
    Isaacs, John
    Pratt, Arthur G.
    Fisher, Benjamin A.
    Buckley, Christopher
    Emery, Paul
    Ho, Pauline
    Buch, Maya H.
    Ciurtin, Coziana
    van Schaardenburg, Dirkjan
    Huizinga, Thomas
    Toes, Rene
    Georgiou, Evangelos
    Kelly, Joanna
    Murphy, Caroline
    Prevost, A. Toby
    [J]. LANCET, 2024, 403 (10429) : 838 - 849
  • [7] Polygenic risk scores: An overview from bench to bedside for personalised medicine
    Cross, Benjamin
    Turner, Richard
    Pirmohamed, Munir
    [J]. FRONTIERS IN GENETICS, 2022, 13
  • [8] Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis
    Galipeau, Heather J.
    Caminero, Alberto
    Turpin, Williams
    Bermudez-Brito, Miriam
    Santiago, Alba
    Libertucci, Josie
    Constante, Marco
    Garay, Juan Antonio Raygoza
    Rueda, Gaston
    Armstrong, Sarah
    Clarizio, Alex
    Smith, Michelle, I
    Surette, Michael G.
    Bercik, Premysl
    Croitoru, Kenneth
    Verdu, Elena F.
    [J]. GASTROENTEROLOGY, 2021, 160 (05) : 1532 - 1545
  • [9] Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives
    Garay, Juan Antonio Raygoza
    Turpin, Williams
    Lee, Sun-Ho
    Smith, Michelle I.
    Goethel, Ashleigh
    Griffiths, Anne M.
    Moayyedi, Paul
    Espin-Garcia, Osvaldo
    Abreu, Maria
    Aumais, Guy L.
    Bernstein, Charles N.
    Biron, Irit A.
    Cino, Maria
    Deslandres, Colette
    Dotan, Iris
    El-Matary, Wael
    Feagan, Brian
    Guttman, David S.
    Huynh, Hien
    Dieleman, Levinus A.
    Hyams, Jeffrey S.
    Jacobson, Kevan
    Mack, David
    Marshall, John K.
    Otley, Anthony
    Panaccione, Remo
    Ropeleski, Mark
    Silverberg, Mark S.
    Steinhart, A. Hillary
    Turner, Dan
    Yerushalmi, Baruch
    Paterson, Andrew D.
    Croitoru, Kenneth
    Xu, W.
    [J]. GASTROENTEROLOGY, 2023, 165 (03) : 670 - 681
  • [10] Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study
    Ghalwash, Mohamed
    Anand, Vibha
    Lou, Olivia
    Martin, Frank
    Rewers, Marian
    Ziegler, Anette-G
    Toppari, Jorma
    Hagopian, William A.
    Veijola, Riitta
    [J]. LANCET CHILD & ADOLESCENT HEALTH, 2023, 7 (04) : 261 - 268