Enantioselective synthesis of silicon-stereogenic siladihydrofuran via copper-catalyzed Si-C bond cleavage

被引：0

作者：

Su, Chuang-Chuang ^{[1
]}

Wu, Yong-Shun ^{[1
]}

Chen, Pan-Pan ^{[1
]}

Wen, An-Jiu ^{[1
]}

Xu, Zheng ^{[1
]}

Ye, Fei ^{[1
]}

Cao, Jian ^{[1
]}

Xu, Li-Wen ^{[1
,2
]}

机构：

[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Zhejiang Key Lab Organosilicon Mat Technol, Key Lab Organosilicon Chem & Mat Technol,Minist Ed, Hangzhou 311121, Peoples R China

[2] Westlake Univ, Sch Sci, Key Lab Precise Synth Funct Mol Zhejiang Prov, Hangzhou, Peoples R China

来源：

JOURNAL OF CATALYSIS | 2025年 / 446卷

基金：

中国国家自然科学基金;

关键词：

Copper catalysis; Catalytic hydrogenation; Asymmetric catalysis; Organosilanes; Heterocycles; C-SP2-TO-O SILYL MIGRATION; ACTIVATION; ARYL;

D O I：

10.1016/j.jcat.2025.116089

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An enantioselective synthesis of silicon-stereogenic siladihydrofuran has been developed. The key for this protocol is Cu-catalyzed Si-C bond cleavage and Si-O bond formation. In addition, catalytic hydrogenation of chiral siladihydrofuran provides carbon- and silicon-stereogenic silatetrahydrofuran in good yields with high diastereoselectivity and enantioselectivity. Ring-opening reactions of silicon-stereogenic siladihydrofuran with organolithium reagents afford enantioenriched functionalized vinylsilanes.

引用

页数：6

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