Enantioselective synthesis of silicon-stereogenic siladihydrofuran via copper-catalyzed Si-C bond cleavage

被引：0
|
作者：
Su, Chuang-Chuang [1 ]
Wu, Yong-Shun [1 ]
Chen, Pan-Pan [1 ]
Wen, An-Jiu [1 ]
Xu, Zheng [1 ]
Ye, Fei [1 ]
Cao, Jian [1 ]
Xu, Li-Wen [1 ,2 ]
机构：
[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Zhejiang Key Lab Organosilicon Mat Technol, Key Lab Organosilicon Chem & Mat Technol,Minist Ed, Hangzhou 311121, Peoples R China
[2] Westlake Univ, Sch Sci, Key Lab Precise Synth Funct Mol Zhejiang Prov, Hangzhou, Peoples R China
来源：
JOURNAL OF CATALYSIS | 2025年 / 446卷
基金：
中国国家自然科学基金;
关键词：
Copper catalysis; Catalytic hydrogenation; Asymmetric catalysis; Organosilanes; Heterocycles; C-SP2-TO-O SILYL MIGRATION; ACTIVATION; ARYL;
D O I：
10.1016/j.jcat.2025.116089
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An enantioselective synthesis of silicon-stereogenic siladihydrofuran has been developed. The key for this protocol is Cu-catalyzed Si-C bond cleavage and Si-O bond formation. In addition, catalytic hydrogenation of chiral siladihydrofuran provides carbon- and silicon-stereogenic silatetrahydrofuran in good yields with high diastereoselectivity and enantioselectivity. Ring-opening reactions of silicon-stereogenic siladihydrofuran with organolithium reagents afford enantioenriched functionalized vinylsilanes.
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页数：6
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