Chemically Modified AsCas12a Guide RNAs Improve Lipid Nanoparticle-Mediated In Vivo Gene Editing in Different Tissues

被引：0

作者：

Wrighton, Paul J. ^{[1
]}

Newmark, Judith ^{[1
]}

Latrick, Chrysa ^{[1
]}

Soman, Vikram ^{[1
]}

Pinilla, Andrea ^{[1
]}

Jones, Mark ^{[1
]}

Quenzer, Eleanor ^{[1
]}

Miller, Alison ^{[1
]}

Bottega, Steve ^{[1
]}

Benedis, Alexis ^{[1
]}

Chica, Bryant ^{[1
]}

Moffet, Bridget ^{[1
]}

Wu, Meng ^{[1
]}

Marco, Eugenio ^{[1
]}

Lele, Swarali ^{[1
]}

Viswanathan, Ramya ^{[1
]}

Wang, He ^{[1
]}

Sun, Xiaoqi ^{[1
]}

Zuris, John A. ^{[1
]}

Bochicchio, James ^{[1
]}

Delano, Kayla ^{[1
]}

Giannoukos, Georgia ^{[1
]}

Chang, Kai-Hsin ^{[1
]}

Pietrasiewicz, Stephen ^{[1
]}

Allocca, Mariacarmela ^{[1
]}

MacLeod, Heather ^{[1
]}

Wolk, Steven ^{[1
]}

机构：

[1] Editas Med, Cambridge, MA USA

来源：

MOLECULAR THERAPY | 2024年 / 32卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

1182

引用

页码：563 / 563

页数：1

共 16 条

[1] Gold Nanoparticle-Mediated Gene Editing for Long Transgene Delivery In Vivo
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Cassidy, Molly E.
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MOLECULAR THERAPY, 2023, 31 (04) : 754 - 755
[2] Quantifying lipid nanoparticle-mediated gene editing and morphological changes in murine retinal pigmented epithelium
Su, Grace Li-Na
Eygeris, Yulia
Curtis, Allison G.
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[3] Lipid nanoparticle-mediated intracameral mRNA delivery facilitates gene expression and editing in the anterior chamber of the eye
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Curtis, Allison G.
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[4] Lipid nanoparticle-mediated CRISPR/Cas9 gene editing and metabolic engineering for anticancer immunotherapy
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[5] Lipid nanoparticle-mediated CRISPR/Cas9 gene editing and metabolic engineering for anticancer immunotherapy
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[6] Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA/sgRNA for gene editing in vitro and in vivo
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2024, 196
[7] In Vivo Prime Editing by Lipid Nanoparticle Co-Delivery of Chemically Modified pegRNA and Prime Editor mRNA
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Kelly, Karen
Cheng, Haoyang
Dong, Xiaolong
Hedger, Adam K.
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GEN BIOTECHNOLOGY, 2023, 2 (06): : 490 - 502
[8] Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin
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Liu, Danny
Mohabatpour, Fatemeh
Ebner, Ronja
Sadhnani, Gaurav
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Leung, Jerry
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An, Kevin
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ACS NANO, 2023, 17 (21) : 22046 - 22059
[9] Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3
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[10] Efficient In utero RNA lipid nanoparticle-mediated gene editing for correction of type 1 tyrosinemia without the AAV-associated genotoxicity
Singh, K.
Riley, R.
Kashyap, M.
White, B.
Bose, S.
Li, H.
Dave, A.
Palanki, R.
Billingsley, M.
Coons, B.
Riley, J.
Zoltick, P.
Everett, J.
Roche, A.
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HUMAN GENE THERAPY, 2021, 32 (19-20) : A68 - A68

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