New Triterpenoids from the Leaves of Heritiera littoralis and Their Anti-Inflammatory Activity

被引：0

作者：

Ren, Chenyang ^{[1
]}

Liang, Xiaoqin ^{[1
]}

Pi, Rui ^{[2
]}

Xin, Jiwen ^{[1
]}

Yang, Bo ^{[1
]}

Zheng, Qingfang ^{[1
]}

Li, Yanqin ^{[1
]}

Li, Jun ^{[1
]}

Zhang, Yanjun ^{[2
]}

机构：

[1] Guangxi Normal Univ, Collaborat Innovat Ctr Guangxi Ethn Med, State Key Lab Chem Mol Engn Med Resources, Key Lab Chem & Mol Engn Med Resources,Minist Educ, Guilin 541004, Peoples R China

[2] Beibu Gulf Univ, Coll Petr & Chem Engn, Guangxi Key Lab Green Chem Mat & Safety Technol, Qinzhou 535000, Peoples R China

来源：

MOLECULES | 2025年 / 30卷 / 01期

关键词：

<italic>Heritiera</italic>; <italic>Heritiera littoralis</italic>; heritiera C; heritiera D; anti-inflammatory; SAPONINS; ACID; CONSTITUENTS; GLYCOSIDES;

D O I：

10.3390/molecules30010131

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new triterpenoids, heritieras C-H (1-6), along with thirteen known triterpenoids (7-19), were isolated from the leaves of Heritiera littoralis. Their structures were identified by spectroscopic analysis, including 1D and 2D nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with the literature. Anti-inflammatory activity of the isolates was evaluated using the lipopolysaccharide (LPS) stimulated RAW 264.7 cell model. Among the isolated triterpenoid, compounds 1, 12, 16, 17, and 18 demonstrated inhibitory activity against nitric oxide (NO) release, in which compound 18 exhibited the best activity with an IC50 value of 18.13 mu M. The potential anti-inflammatory mechanism was investigated using molecular docking. The triterpenoids from H. littoralis could be served as potential candidates for the development of new anti-inflammatory agents.

引用

页数：15

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