Skin-Interfaced Wearable Sensor for Long-Term Reliable Monitoring of Uric Acid and pH in Sweat

被引：0

作者：

Jiang, Danfeng ^{[1
]}

Liu, Xiaohu ^{[2
]}

Zhan, Wenjun ^{[1
]}

Fu, Mengmeng ^{[1
]}

Liu, Jiacheng ^{[1
]}

He, Jialun ^{[1
]}

Li, Yunlong ^{[1
]}

Li, Yingguo ^{[1
]}

Chen, Xiao ^{[1
]}

Yu, Chao ^{[1
]}

机构：

[1] Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang 212003, Jiangsu, Peoples R China

[2] Wenzhou Med Univ, Eye Hosp, Sch Biomed Engn, Sch Ophthalmol & Optometry, Wenzhou 325001, Zhejiang, Peoples R China

来源：

NANO LETTERS | 2025年 / 25卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Wearable sensor; gout management; pH calibration; simultaneous detection; reliablemonitoring; PATCH;

D O I：

10.1021/acs.nanolett.4c05156

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Wearable sweat sensors offering real-time monitoring of biomarker levels suffer from stability and accuracy issues, primarily due to low biomarker concentrations, fluctuating sweat pH, and material detachment from sensor deformation. Here, we developed a wearable sensing system integrated with two advanced electrodes and a flexible microchannel for long-term reliable monitoring of sweat pH and uric acid (UA). By printing the ink doped with nanomaterials (Co3O4@CuCo2O4 and polyaniline), we achieved highly stable electrodes for the direct analysis of perspiration, without additional surface modification. Additionally, real-time pH analysis provided a means for sensitivity calibration, reducing the effect of individual metabolism and exercise intensity. As a result, the wearable sensing system for effective gout management was validated by accurately tracking the UA fluctuations in serum and sweat of hyperuricemia patients and healthy individuals. These findings offer a reliable method for tracking biomarkers to assess personal health.

引用

页码：1427 / 1435

页数：9

共 35 条

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