Host Defense Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Activities toward Phytopathogens to Alleviate Antimicrobial Resistance in Agriculture

被引:0
作者
Chen, Sheng [1 ]
Zhou, Min [1 ]
Xiao, Ximian [1 ]
Xie, Jiayang [1 ]
Liu, Longqiang [1 ]
Cong, Zihao [1 ]
Zhao, Xuebin [1 ]
Hu, Weilong [1 ]
Wang, Jie [2 ,3 ]
Song, Gonghua [4 ]
Liu, Runhui [1 ,5 ,6 ]
机构
[1] East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China
[2] China Railway Acad Grp Co Ltd, Chengdu 610032, Sichuan, Peoples R China
[3] China Railway Cultural Heritage Rehabil Technol In, Chengdu 610032, Sichuan, Peoples R China
[4] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai, Peoples R China
[5] East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat, Engn Res Ctr Biomed Mat,Minist Educ,Sch Mat Sci &, Shanghai 200237, Peoples R China
[6] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China
基金
中国国家自然科学基金;
关键词
host defense peptides; poly(2-oxazoline)s; phytopathogens; antimicrobial resistance; BROAD-SPECTRUM; PLANTS; INFECTIONS; CHALLENGES; MANAGEMENT; PROTEINS; BACTERIA; FUNGAL;
D O I
10.1021/acs.jafc.4c12430
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Given the limited types of agricultural bactericides and the rapid emergence of antimicrobial resistance, bacterial plant diseases pose a serious threat to agricultural production, which calls for effective antimicrobial agents with a low propensity for resistance. Host defense peptides (HDPs) have drawn significant attention for their broad-spectrum antimicrobial activity. In this study, we found that HPD-mimicking poly(2-oxazoline) Gly-POX20 exhibits potent activity against bacterial phytopathogens, with superior antibacterial selectivity and proteolytic stability compared to the natural HDP melittin. Compared to commonly used agricultural bactericides, Gly-POX20 displays more efficient antibiofilm activity and a lower propensity for resistance than does the antibiotic streptomycin, likely due to its antibacterial mechanism, which involves DNA interaction and generating lethal doses of ROS. In vivo studies reveal that Gly-POX20 is effective in preventing and treating phytopathogens without observable damage to plant tissues, suggesting that poly(2-oxazoline) could be a promising bactericide for agricultural applications.
引用
收藏
页码:8191 / 8203
页数:13
相关论文
共 60 条
  • [1] Synthetic Peptides against Plant Pathogenic Bacteria
    Badosa, Esther
    Planas, Marta
    Feliu, Lidia
    Montesinos, Laura
    Bonaterra, Anna
    Montesinos, Emilio
    [J]. MICROORGANISMS, 2022, 10 (09)
  • [2] Large-scale manufacture of peptide therapeutics by chemical synthesis
    Bray, BL
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (07) : 587 - 593
  • [3] Through the wall: extracellular vesicles in Gram-positive bacteria, mycobacteria and fungi
    Brown, Lisa
    Wolf, Julie M.
    Prados-Rosales, Rafael
    Casadevall, Arturo
    [J]. NATURE REVIEWS MICROBIOLOGY, 2015, 13 (10) : 620 - 630
  • [4] Antibacterial activity and mechanism of Protocatechuic acid against bacterial canker of tomato fruits caused by Clavibacter michiganensis subsp. michiganensis
    Cai, Jin
    Sun, Lijuan
    Wang, Qi
    [J]. FOOD BIOSCIENCE, 2024, 60
  • [5] The dynamics and transmission of antibiotic resistance associated with plant microbiomes
    Chen, Ping
    Yu, Kaifeng
    He, Yiliang
    [J]. ENVIRONMENT INTERNATIONAL, 2023, 176
  • [6] Host Defense Peptide Mimicking Peptide Polymer Exerting Fast, Broad Spectrum, and Potent Activities toward Clinically Isolated Multidrug-Resistant Bacteria
    Chen, Sheng
    Shao, Xiaoyan
    Xiao, Ximian
    Dai, Yidong
    Wang, Yun
    Xie, Jiayang
    Jiang, Weinan
    Sun, Yun
    Cong, Zihao
    Qiao, Zhongqian
    Zhang, Haodong
    Liu, Longqiang
    Zhang, Qiang
    Zhang, Wenjing
    Zheng, Liang
    Yu, Bingran
    Chen, Minzhang
    Cui, Wenguo
    Fei, Jian
    Liu, Runhui
    [J]. ACS INFECTIOUS DISEASES, 2020, 6 (03): : 479 - 488
  • [7] From Natural Product Derivative to Hexagonal Prism Supermolecule: Potent Biofilm Disintegration, Enhanced Foliar Affinity, and Effective Management of Tomato Bacterial Canker
    Chen, Xue
    Yang, Run
    Liu, Kongjun
    Liu, Min
    Shi, Qingchuan
    Yang, Jinghan
    Hao, Gefei
    Luo, Laixin
    Du, Fengpei
    Wang, Peiyi
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 64 (08)
  • [8] Peptide-mimicking poly(2-oxazoline) displaying potent antibacterial and antibiofilm activities against multidrug-resistant Gram-positive pathogenic bacteria
    Cong, Zihao
    Yan, Zi
    Xiao, Ximian
    Liu, Longqiang
    Luo, Zhengjie
    Zou, Jingcheng
    Chen, Minzhang
    Wu, Yueming
    Zhou, Min
    Liu, Runhui
    [J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY, 2025, 214 : 233 - 244
  • [9] Antibiotics induce redox-related physiological alterations as part of their lethality
    Dwyer, Daniel J.
    Belenky, Peter A.
    Yang, Jason H.
    MacDonald, I. Cody
    Martell, Jeffrey D.
    Takahashi, Noriko
    Chan, Clement T. Y.
    Lobritz, Michael A.
    Braff, Dana
    Schwarz, Eric G.
    Ye, Jonathan D.
    Pati, Mekhala
    Vercruysse, Maarten
    Ralifo, Paul S.
    Allison, Kyle R.
    Khalil, Ahmad S.
    Ting, Alice Y.
    Walker, Graham C.
    Collins, James J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (20) : E2100 - E2109
  • [10] Worldwide emergence of resistance to antifungal drugs challenges human health and food security
    Fisher, Matthew C.
    Hawkins, Nichola J.
    Sanglard, Dominique
    Gurr, Sarah J.
    [J]. SCIENCE, 2018, 360 (6390) : 739 - 742