MRI detects tubulointerstitial changes in mouse models of radiation-induced nephropathy

被引：0
作者：
Stabinska, Julia [1 ,2 ]
Piccolo, Joe [2 ]
Chhabra, Anupriya [2 ]
Liatsou, Ioanna [2 ]
Gabrielson, Kathy [3 ]
Li, Zhi [2 ]
Mohanta, Zinia [1 ,2 ]
Sedaghat, Farzad [2 ]
Hobbs, Robert F. [2 ]
Sgouros, George [2 ]
Mcmahon, Michael T. [1 ,2 ]
机构：
[1] Kennedy Krieger Inst, FM Kirby Res Ctr Funct Brain Imaging, 707 N Broadway, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Med, Dept Mol & Comparat Pathobiol, Baltimore, MD USA
来源：
MAGNETIC RESONANCE IN MEDICINE | 2025年
基金：
美国国家卫生研究院;
关键词：
actinium-225; external beam radiotherapy; kidney; MRI; radiation nephropathy; RELAXATION-TIME; KIDNEY; TISSUE;
D O I：
10.1002/mrm.30443
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose We hypothesized that radiation-induced tubulointerstitial changes in the kidney can be assessed using MRI-based T-2 relaxation time measurements. Methods We performed MRI, histology, and serum biochemistry in two mouse models of radiation nephropathy: one involving external beam radiotherapy and the other using internal irradiation with an alpha-particle-emitting actinium-225 radiolabeled antibody. We compared the mean T2 values of different renal compartments between control and external beam radiotherapy or alpha-particle-emitting actinium-225 radiolabeled antibody-treated groups and between the two radiation-treated groups using a Wilcoxon rank-sum test. Results Significantly higher T-2 values were found in the cortex and outer stripe of the outer medulla in all treated animals compared with the control group (p < 0.05). In addition, these changes in T-2 were observed before any changes in serum parameters, animal body weight, and kidney volume occurred. Conclusion T-2 mapping is sensitive to radiation-induced tubulointerstitial changes in the kidney.
引用
收藏
页码：251 / 261
页数：11
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