A Novel Effect of Allium tuncelianum Extract: Topical Application Improves Wound Healing in a Nasal Septal Perforation Rat Model

Objective: The objective of the current study was to investigate the influence of Allium tuncelianum (AT) extract on wound healing in a nasal septum perforation (NSP) model. Methods: Twenty-two healthy male Sprague-Dawley rats were included in this study and separated into two groups. A standardized NSP was created in each subject. A 0.09% saline (control group) and the 25% AT solution (study group) were delivered intranasally daily for 14 days. At the end of the experiment, the subjects were sacrificed and the septa were excised for histopathological investigation. The macroscopic closure rate of NSP, intranasal pH, counts of acute inflammatory cells, eosinophil, fibroblast, and giant cell, epithelial regeneration and degeneration, vascularization, granulation formation, collagen density, cartilage regeneration, and degeneration were examined. The obtained data were analyzed statistically. Results: The macroscopic closure rate (p = 0.006), the fibroblast number (p = 0.003), vascularization (p = 0.003), collagen density (p = 0.044), and granulation tissue amount (p = 0.022) were found to be significantly higher in AT group. However, the acute inflammatory cells count was significantly lower in AT group (p = 0.031) (p < 0.05). Conclusion: The topically delivered AT extract may improve wound healing in an experimental NSP model. Consequently, the local application of AT might be promising to prevent the formation of NSP.