Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024

被引:0
|
作者
Pei, Yanhong [1 ]
Liang, Haijie [1 ]
Guo, Yu [1 ]
Wang, Boyang [1 ]
Wu, Han [1 ]
Jin, Zhijian [1 ]
Lin, Shanyi [1 ]
Zeng, Fanwei [1 ]
Wu, Yifan [1 ]
Shi, Qianyu [1 ]
Xu, Jiuhui [1 ]
Huang, Yi [1 ]
Ren, Tingting [1 ]
Liu, Jiarui [2 ,3 ]
Guo, Wei [1 ]
机构
[1] Peking Univ Peoples Hosp, Dept Bone Tumor, Beijing, Peoples R China
[2] Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Anat Histol & Embryol, Beijing, Peoples R China
[3] Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2025年 / 15卷
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
liquid liquid phase separation (LLPS); immune transduction; bibliometric; CiteSpace; cancer; CELL ANTIGEN RECEPTOR; CYCLIC GMP-AMP; UBIQUITIN LIGASE; PROTEIN; INNATE; MECHANISMS; PROMOTES; EVASION; TRANSITION; BINDING;
D O I
10.3389/fonc.2025.1509457
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Liquid-liquid phase separation (LLPS) is a novel concept that could explain how living cells precisely modulate internal spatial and temporal functions. However, a comprehensive bibliometric analysis on LLPS and immune signaling processes in cancer is still scarce. This study aims to perform a bibliometric assessment of research to explore the landscape of LLPS research in immune signaling pathways for cancer. Methods Utilizing the Web of Science Core Collection database and multiple analysis software, we performed quantitative and qualitative analyses of the study situation between LLPS and immune signaling in cancer from 1992 to 2024. Results The corresponding authors were primarily from China and the USA. The most relevant references were the "International Journal of Molecular Sciences", "Proteomics". The annual number of publications exhibited a fast upward tendency from 2020 to 2024. The most frequent key terms included expression, separation, activation, immunotherapy, and mechanisms. Qualitative evaluation emphasized the TCR, BCR, cGAS-STING, RIG-1, NF-kappa B signaling pathways associated with LLPS processes. Conclusion This research is the first to integratively map out the knowledge structure and forward direction in the area of immune transduction linked with LLPS over the past 30 years. In summary, although this research area is still in its infancy, illustrating the coordinated structures and communications between cancer and immune signaling with LLPS within a spatial framework will offer deeper insights into the molecular mechanisms of cancer development and further enhance the effectiveness of existing immunotherapies.
引用
收藏
页数:20
相关论文
共 50 条
  • [1] Liquid-liquid phase separation drives cellular function and dysfunction in cancer
    Mehta, Sohum
    Zhang, Jin
    NATURE REVIEWS CANCER, 2022, 22 (04) : 239 - 252
  • [2] Emerging Roles of Liquid-Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling
    Lu, Jiahua
    Qian, Junjie
    Xu, Zhentian
    Yin, Shengyong
    Zhou, Lin
    Zheng, Shusen
    Zhang, Wu
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [3] Liquid-Liquid Phase Separation in Cancer Signaling, Metabolism and Anticancer Therapy
    Igelmann, Sebastian
    Lessard, Frederic
    Ferbeyre, Gerardo
    CANCERS, 2022, 14 (07)
  • [4] Liquid-liquid phase separation drives herpesvirus assembly in the cytoplasm
    Chung, Woo-Chang
    Ahn, Jin-Hyun
    Song, Moon Jung
    JOURNAL OF CELL BIOLOGY, 2022, 222 (01):
  • [5] Liquid-liquid phase separation drives skin barrier formation
    Quiroz, Felipe Garcia
    Fiore, Vincent F.
    Levorse, John
    Polak, Lisa
    Wong, Ellen
    Pasolli, H. Amalia
    Fuchs, Elaine
    SCIENCE, 2020, 367 (6483) : 1210 - +
  • [6] Liquid-liquid phase separation in cellular signaling systems
    Chong, P. Andrew
    Forman-Kay, Julie D.
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2016, 41 : 180 - 186
  • [7] Dehydration entropy drives liquid-liquid phase separation by molecular crowding
    Park, Sohee
    Barnes, Ryan
    Lin, Yanxian
    Jeon, Byoung-jin
    Najafi, Saeed
    Delaney, Kris T.
    Fredrickson, Glenn H.
    Shea, Joan-Emma
    Hwang, Dong Soo
    Han, Songi
    COMMUNICATIONS CHEMISTRY, 2020, 3 (01)
  • [8] Liquid-liquid phase separation drives the β-catenin destruction complex formation
    Shi, Qiaoni
    Kang, Kexin
    Chen, Ye-Guang
    BIOESSAYS, 2021, 43 (10)
  • [9] Dehydration entropy drives liquid-liquid phase separation by molecular crowding
    Sohee Park
    Ryan Barnes
    Yanxian Lin
    Byoung-jin Jeon
    Saeed Najafi
    Kris T. Delaney
    Glenn H. Fredrickson
    Joan-Emma Shea
    Dong Soo Hwang
    Songi Han
    Communications Chemistry, 3
  • [10] Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling
    Wu, Xiandeng
    Cai, Qixu
    Feng, Zhe
    Zhang, Mingjie
    DEVELOPMENTAL CELL, 2020, 55 (01) : 18 - 29