Atherosclerosis, Cancer and Immune Checkpoint Inhibitors

被引：0

作者：

Canale, Maria Laura ^{[1
]}

Greco, Alessandra ^{[2
]}

Inno, Alessandro ^{[3
]}

Tedeschi, Andrea ^{[4
]}

De Biasio, Marzia ^{[5
]}

Oliva, Stefano ^{[6
]}

Bisceglia, Irma ^{[7
]}

Maurea, Nicola ^{[8
]}

Tarantini, Luigi ^{[9
]}

Gallucci, Giuseppina ^{[10
]}

Gulizia, Michele Massimo ^{[11
]}

Turazza, Fabio Maria ^{[12
]}

Luca, Fabiana ^{[13
]}

Di Fusco, Stefania Angela ^{[14
]}

Riccio, Carmine ^{[15
]}

Navazio, Alessandro ^{[9
]}

De Luca, Leonardo ^{[2
]}

Gabrielli, Domenico ^{[16
,17
]}

Colivicchi, Furio ^{[14
]}

Grimaldi, Massimo ^{[18
]}

Oliva, Fabrizio ^{[19
]}

机构：

[1] Osped Versilia, Azienda USL Toscana Nord Ovest, UOC Cardiol, Lido Di Camaiore, LU, Italy

[2] Fdn IRCCS Policlin San Matteo, Div Cardiol, Pavia, Italy

[3] IRCCS Osped Sacro Cuore Don Calabria, Oncol Med, Negrar Di Valpolicella, VR, Italy

[4] Osped Civile Guglielmo da Saliceto, UOC Cardiol & UT, Piacenza, Italy

[5] Azienda Sanit Univ Friuli Cent, Cardiol, Udine, Italy

[6] IRCCS Ist Tumori Giovanni Paolo II, UOSD Cardiol Interesse Oncol, Bari, Italy

[7] Azienda Osped San Camillo Forlanini, Dipartimento Sci Cardiotoraco Vasc, Serv Cardiol Integrati, Rome, Italy

[8] IRCCS, Fdn G Pascale, SC Cardiol, Naples, Italy

[9] AUSL IRCCS Reggio Emilia, Cardiol Osped, Reggio Emilia, Italy

[10] Polimedica, Melfi, PZ, Italy

[11] Osped Garibaldi Nesima, UOC Cardiol, UOC Cardiol, Catania, Italy

[12] Fdn IRCCS, SC Cardiol, Milan, Italy

[13] Azienda Ospedaliera Bianchi Melacrino Morelli, Cardiol Interventist UTIC, Azienda Osped Bianchi Melacrino Morelli, Reggio Di Calabria, Italy

[14] Presidio Osped San Filippo Neri ASL Roma 1, UOC Cardiol Clin & Riabil, Rome, Italy

[15] AORN St Anna & San Sebastiano, Dipartimento Cardiovasc, Caserta, Italy

[16] Azienda Osped San Camillo Forlanini, UOC Cardiol, Rome, Italy

[17] Fdn Tuo Cuore Heart Care Fdn, Florence, Italy

[18] Osped Gen Regionale F Miulli, UOC Cardiol, Acquaviva Delle Fonti, BA, Italy

[19] ASST Grande Osped Metropolitano Niguarda, Dipartimento Cardiotoracovasc A De Gasperis, Cardiol Emodinam 1, Milan, Italy

来源：

GIORNALE ITALIANO DI CARDIOLOGIA | 2024年 / 25卷 / 10期

关键词：

Atherosclerosis; Cancer; Immune checkpoint inhibitors; Immunotherapy; CARDIOVASCULAR EVENTS; CORONARY CALCIUM; ADVERSE EVENTS; LUNG-CANCER; IMMUNOTHERAPY; INFLAMMATION; MANAGEMENT; BLOCKADE; SEX; CALCIFICATION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunotherapy has revolutionized the treatment of various cancers leading to a clear survival benefit with cured or long-surviving patients. Atherosclerosis and cancer share risk factors and molecular mechanisms and have as their common thread a state of chronic inflammation linked to a deregulation of the immune system. A growing body of evidence is accumulating on the potential worsening effect of immune checkpoint inhibitors on atherosclerosis, with subsequent worsening of patients' long-term cardiovascular risk. The molecular pathways implicated in the growth and deregulation of atherosclerotic plaques seem to be the same (CTLA-4, PD-1, PD-L1) as those on which the anti-tumor effect is exerted. Owing to the increasing number of cancer patients treated with immunotherapy and the improved survival with the possibility of prolonged disease control, it is necessary to know the potential increase in cardiovascular risk for atherosclerosis-related events and to establish all prevention measures to reduce it.

引用

页码：711 / 719

页数：9

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