The Role of Circulating Fatty Acids in Mediating the Effect of Insomnia on Heart Failure: A Two-Step, Two-Sample Mendelian Randomization Study

被引：0
作者：
Zuo, Bo [1 ]
Yu, Binhe [2 ]
Wang, Pengwei [2 ,3 ]
Zhang, Chong [1 ]
Zhao, Chenhao [2 ]
Sun, Yujing [2 ]
Ai, Sizhi [2 ,4 ,5 ,6 ,7 ]
机构：
[1] Capital Med Univ, Beijing Friendship Hosp, Cardiovasc Ctr, Dept Cardiol, Beijing, Peoples R China
[2] Xinxiang Med Univ, Life Sci Res Ctr, Affiliated Hosp 1, Dept Cardiol, 88 Jiankang Rd, Xinxiang 453100, Weihui, Peoples R China
[3] Xinxiang Med Univ, Clin Coll 4, Xinxiang, Peoples R China
[4] Guangzhou Med Univ, Affiliated Brain Hosp, Ctr Sleep & Circadian Med, Guangzhou, Guangdong, Peoples R China
[5] Guangzhou Med Univ, Key Lab Neurogenet & Channelopathies Guangdong Pro, Guangzhou, Guangdong, Peoples R China
[6] Guangzhou Med Univ, Minist Educ China, Guangzhou, Guangdong, Peoples R China
[7] Guangzhou Med Univ, Affiliated Brain Hosp, Inst Psychoneurosci, Guangzhou, Guangdong, Peoples R China
来源：
NATURE AND SCIENCE OF SLEEP | 2025年 / 17卷
基金：
中国国家自然科学基金;
关键词：
Mendelian randomization; insomnia; heart failure; circulating fatty acids; CARDIOVASCULAR-DISEASES; SLEEP RESTRICTION; RISK; SYMPTOMS; OMEGA-3;
D O I：
10.2147/NSS.S471466
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose: Previous studies support the causal effect of insomnia on heart failure. Fatty acid metabolism plays key roles in the occurrence and development of heart failure. It is unclear whether fatty acids play roles in the causal association between insomnia and heart failure. This study aims to investigate the mediating role of fatty acids in the association between insomnia and heart failure. Methods: We performed two-step, two-sample Mendelian randomization analysis by applying SNPs as genetic instruments for exposures, mediators and outcomes. Summary data obtained from genome-wide association studies for insomnia, proposed fatty acid mediators and heart failure were used in this study. The overall effect of insomnia on heart failure includes direct and indirect effects. Results: Genetically predicted insomnia has a significant causal effect on circulating total fatty acids, saturated fatty acids, monounsaturated fatty acids and omega-3 fatty acids. In addition, different circulating fatty acids have no causal effect on insomnia incidence. A significant positive correlation between genetic predicted insomnia and heart failure (OR = 1.10, 95% CI: 1.06-1.14, P<0.001) was observed. Finally, we found that circulating fatty acids play a mediating role in the causal association between insomnia and heart failure. Total fatty acids, saturated fatty acids and monounsaturated fatty acids explained 3% (95% CI: 0%-7.5%), 3% (95% CI: -1.1%-7.5%), 4% (95% CI: 0%- 9.7%) of the overall effect of insomnia on heart failure, respectively. Conclusion: These results support circulating fatty acids as potential mediators in the causal association between insomnia and heart failure.
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收藏
页码：391 / 399
页数：9
相关论文
共 35 条
  • [1] Kittleson MM., Management of heart failure in hospitalized patients, Ann Intern Med, 176, 12, pp. ITC177-ITC192, (2023)
  • [2] Aquino G, Benz F, Dressle RJ, Et al., Towards the neurobiology of insomnia: a systematic review of neuroimaging studies, Sleep Med Rev, 73, (2023)
  • [3] Mahmood A, Ray M, Dobalian A, Ward KD, Ahn S., Insomnia symptoms and incident heart failure: a population-based cohort study, Eur Heart J, 42, 40, pp. 4169-4176, (2021)
  • [4] Zheng B, Yu C, Lv J, Et al., China kadoorie biobank collaborative, insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: a 10-year cohort, Neurology, 93, 23, pp. e2110-e2120, (2019)
  • [5] Sofi F, Cesari F, Casini A, Macchi C, Abbate R, Gensini GF., Insomnia and risk of cardiovascular disease: a meta-analysis, Eur J Prev Cardiol, 21, 1, pp. 57-64, (2014)
  • [6] Stinkens R, Goossens GH, Jocken JW, Blaak EE., Targeting fatty acid metabolism to improve glucose metabolism, Obes Rev, 16, 9, pp. 715-757, (2015)
  • [7] Henderson GC., Plasma free fatty acid concentration as a modifiable risk factor for metabolic disease, Nutrients, 13, 8, (2021)
  • [8] Opie LH, Knuuti J., The adrenergic-fatty acid load in heart failure, J Am Coll Cardiol, 54, 18, pp. 1637-1646, (2009)
  • [9] Barbarawi M, Lakshman H, Barbarawi O, Et al., Omega-3 supplementation and heart failure: a meta-analysis of 12 trials including 81,364 participants, Contemp Clin Trials, 107, (2021)
  • [10] Stefanovski D, Boston RC, Punjabi NM., Sleep-disordered breathing and free fatty acid metabolism, Chest, 158, 5, pp. 2155-2164, (2020)
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