Two unprecedented 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones with anti-Helicobacter pylori activity from agarwood of Aquilaria sinensis 'Reke 1'

被引：0
|
作者：
Qin, Ke-Xin [1 ,2 ,3 ]
Wang, Hao [2 ,3 ]
Yang, Li [2 ,3 ]
Wei, Yan-Mei [2 ,3 ]
Cai, Cai-Hong [2 ,3 ]
Chen, Hui-Qin [2 ,3 ]
Dong, Wen-Hua [2 ,3 ]
Li, Wei [2 ,3 ]
Yan, Xian-Yun [2 ,3 ]
Zeng, Jun [2 ,3 ]
Mei, Wen-Li [2 ,3 ]
Jian, Jie [1 ]
Dai, Haofu [2 ,3 ]
机构：
[1] Guilin Med Univ, Coll Pharm, Guilin 541004, Peoples R China
[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Int Joint Res Ctr Agarwood, Hainan Engn Res Ctr Agarwood, Haikou 571101, Peoples R China
[3] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2025年 / 66卷
关键词：
Agarwood; Aquilaria sinensis 'Reke 1 '; 2-(2-Phenylethyl)chromone; Anti -Helicobacter pylori activity; 2-(2-PHENYLETHYL)CHROMONES;
D O I：
10.1016/j.phytol.2025.01.1002
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones (1 and 2), together with one known compound (3), were isolated from the ethanol extract of agarwood produced from Aquilaria sinensis 'Reke 1'. The structures of compounds 1 and 2 were precisely elucidated on the basis of HR-ESI-MS, 1D and 2D NMR, TDDFT-ECD, as well as by comparison with the literature data. All compounds were evaluated for anti-Helicobacter pylori activity. Compound 2 exhibited significant inhibitory effect against H. pylori with the minimum inhibition concentration (MIC) value of 20 mu M.
引用
收藏
页码：77 / 80
页数：4
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