Two unprecedented 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones with anti-Helicobacter pylori activity from agarwood of Aquilaria sinensis 'Reke 1'

被引：0

作者：

Qin, Ke-Xin ^{[1
,2
,3
]}

Wang, Hao ^{[2
,3
]}

Yang, Li ^{[2
,3
]}

Wei, Yan-Mei ^{[2
,3
]}

Cai, Cai-Hong ^{[2
,3
]}

Chen, Hui-Qin ^{[2
,3
]}

Dong, Wen-Hua ^{[2
,3
]}

Li, Wei ^{[2
,3
]}

Yan, Xian-Yun ^{[2
,3
]}

Zeng, Jun ^{[2
,3
]}

Mei, Wen-Li ^{[2
,3
]}

Jian, Jie ^{[1
]}

Dai, Haofu ^{[2
,3
]}

机构：

[1] Guilin Med Univ, Coll Pharm, Guilin 541004, Peoples R China

[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Int Joint Res Ctr Agarwood, Hainan Engn Res Ctr Agarwood, Haikou 571101, Peoples R China

[3] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Res & Dev Nat Prod Li Folk Med Hainan Prov, Haikou 571101, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2025年 / 66卷

关键词：

Agarwood; Aquilaria sinensis 'Reke 1 '; 2-(2-Phenylethyl)chromone; Anti -Helicobacter pylori activity; 2-(2-PHENYLETHYL)CHROMONES;

D O I：

10.1016/j.phytol.2025.01.1002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones (1 and 2), together with one known compound (3), were isolated from the ethanol extract of agarwood produced from Aquilaria sinensis 'Reke 1'. The structures of compounds 1 and 2 were precisely elucidated on the basis of HR-ESI-MS, 1D and 2D NMR, TDDFT-ECD, as well as by comparison with the literature data. All compounds were evaluated for anti-Helicobacter pylori activity. Compound 2 exhibited significant inhibitory effect against H. pylori with the minimum inhibition concentration (MIC) value of 20 mu M.

引用

页码：77 / 80

页数：4

共 43 条

[1] Anti-inflammatory 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones from agarwood of Aquilaria sinensis
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[2] 5,6,7,8-Tetrahydro-2-(2-phenylethyl)chromones from artificial agarwood of Aquilaria sinensis and their inhibitory activity against acetylcholinesterase
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[10] Two new 2-(2-phenylethyl)chromone derivatives and two sesquiterpenes from agarwood of Aquilaria sinensis with anti-inflammatory activity
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