Targeting fatty acid oxidation: A potential strategy for treating gastrointestinal tumors

被引：0
|
作者：
Zheng, Yingsong [1 ]
Jiang, Zhengchen [2 ]
Yuan, Li [3 ]
Cheng, Xiangdong [2 ]
He, Weiyang [4 ]
Chen, Xiaodong [4 ]
机构：
[1] Wenzhou Med Univ, Zhejiang Canc Hosp, Postgrad Training Base Alliance, Hangzhou, Peoples R China
[2] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Dept Gastr Surg, Hangzhou, Peoples R China
[3] Zhejiang Canc Hosp, Zhejiang Key Lab Prevent Diag & Therapy Upper Gast, Hangzhou, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc, Dept Gastr Surg,Sichuan Canc Ctr,Affiliated Canc H, Chengdu 610041, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CANCER | 2025年
关键词：
CPT1; FAO; gastrointestinal tumor; ROS; tumor microenvironment; ALPHA-OXIDATION; BETA-OXIDATION; CELL SURVIVAL; CANCER-CELLS; METABOLISM; METASTASIS; TISSUE; PREADIPOCYTES; RESISTANCE; HYPOXIA;
D O I：
10.1002/ijc.35380
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastrointestinal cancers including esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), and colorectal cancer (CRC) are common and highly lethal types of cancer worldwide. Metabolic reprogramming plays a critical role in cancer progression and involves metabolic processes such as glucose and lipid metabolism. Fatty acid oxidation (FAO) has a profound impact on cancer, with many genes and cytokines influencing cancer cell initiation, development, metastasis, and resistance by regulating FAO. Additionally, FAO further promotes cancer progression by affecting the tumor microenvironment (TME). The role of FAO in gastrointestinal cancers has garnered increasing attention, and related anticancer drugs are currently being developed.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Targeting tumor-associated macrophages: A potential treatment for solid tumors
    Chen, Yibing
    Jin, Huan
    Song, Yucen
    Huang, Ting
    Cao, Jun
    Tang, Qing
    Zou, Zhengzhi
    JOURNAL OF CELLULAR PHYSIOLOGY, 2021, 236 (05) : 3445 - 3465
  • [32] Fatty acid oxidation is critical for the tumorigenic potential and chemoresistance of pancreatic cancer stem cells
    Mascaraque, Marta
    Courtois, Sarah
    Royo-Garcia, Alba
    Barneda, David
    Stoian, Andrei M.
    Villaoslada, Isabel
    Espiau-Romera, Pilar
    Bokil, Ansooya
    Cano-Galiano, Andres
    Jagust, Petra
    Heeschen, Christopher
    Sancho, Patricia
    JOURNAL OF TRANSLATIONAL MEDICINE, 2024, 22 (01)
  • [33] Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC
    Tanaka, Masatake
    Masaki, Yuko
    Tanaka, Kosuke
    Miyazaki, Masayuki
    Kato, Masaki
    Sugimoto, Rie
    Nakamura, Kazuhiko
    Aishima, Shinichi
    Shirabe, Ken
    Nakamuta, Makoto
    Enjoji, Munechika
    Kotoh, Kazuhiro
    Takayanagi, Ryoichi
    MOLECULAR MEDICINE REPORTS, 2013, 7 (02) : 365 - 370
  • [34] Targeting c-Jun inhibits fatty acid oxidation to overcome tamoxifen resistance in estrogen receptor-positive breast cancer
    Jiang, Cen
    Zhu, Youzhi
    Chen, Huaying
    Lin, Junyu
    Xie, Ruiwang
    Li, Weiwei
    Xue, Jiajie
    Chen, Ling
    Chen, Xiangjin
    Xu, Sunwang
    CELL DEATH & DISEASE, 2023, 14 (10)
  • [35] Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion
    Jiang, Nian
    Xie, Bowen
    Xiao, Wenwu
    Fan, Ming
    Xu, Shanxiu
    Duan, Yixin
    Hamsafar, Yamah
    Evans, Angela C.
    Huang, Jie
    Zhou, Weibing
    Lin, Xuelei
    Ye, Ningrong
    Wanggou, Siyi
    Chen, Wen
    Jing, Di
    Fragoso, Ruben C.
    Dugger, Brittany N.
    Wilson, Paul F.
    Coleman, Matthew A.
    Xia, Shuli
    Li, Xuejun
    Sun, Lun-Quan
    Monjazeb, Arta M.
    Wang, Aijun
    Murphy, William J.
    Kung, Hsing-Jien
    Lam, Kit S.
    Chen, Hong-Wu
    Li, Jian Jian
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [36] The role of fatty acid β-oxidation in lymphangiogenesis
    Wong, Brian W.
    Wang, Xingwu
    Zecchin, Annalisa
    Thienpont, Bernard
    Cornelissen, Ivo
    Kalucka, Joanna
    Garcia-Caballero, Melissa
    Missiaen, Rindert
    Huang, Hongling
    Burning, Ulrike
    Blacher, Silvia
    Vinckier, Stefan
    Goveia, Jermaine
    Knobloch, Marlen
    Zhao, Hui
    Dierkes, Cathrin
    Shi, Chenyan
    Haegerling, Rene
    Moral-Darde, Veronica
    Wyns, Sabine
    Lippens, Martin
    Jessberger, Sebastian
    Fendt, Sarah-Maria
    Luttun, Aernout
    Noel, Agnes
    Kiefer, Friedemann
    Ghesquiere, Bart
    Moons, Lieve
    Schoonjans, Luc
    Dewerchin, Mieke
    Eelen, Guy
    Lambrechts, Diether
    Carmeliet, Peter
    NATURE, 2017, 542 (7639) : 49 - +
  • [37] Alterations of fatty acid β-oxidation capability in the liver of ketotic cows
    Li, P.
    Li, X. B.
    Fu, S. X.
    Wu, C. C.
    Wang, X. X.
    Yu, G. J.
    Long, M.
    Wang, Z.
    Liu, G. W.
    JOURNAL OF DAIRY SCIENCE, 2012, 95 (04) : 1759 - 1766
  • [38] Targeting Gremlin 1 Prevents Intestinal Fibrosis Progression by Inhibiting the Fatty Acid Oxidation of Fibroblast Cells
    Yang, Yang
    Zeng, Qi-Shan
    Zou, Min
    Zeng, Jian
    Nie, Jiao
    Chen, DongFeng
    Gan, Hua-Tian
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [39] Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition
    Nassar, Zeyad D.
    Mah, Chui Yan
    Centenera, Margaret M.
    Irani, Swati
    Sadowski, Martin C.
    Scott, Julia S.
    Nguyen, Elizabeth, V
    Nagarajan, Shilpa R.
    Moldovan, Max
    Lynn, David J.
    Daly, Roger J.
    Hoy, Andrew J.
    Butler, Lisa M.
    MOLECULAR CANCER RESEARCH, 2020, 18 (10) : 1500 - 1511
  • [40] The Potential of 11C-acetate PET for Monitoring the Fatty Acid Synthesis Pathway in Tumors
    DeFord-Watts, Laura M.
    Mintz, Akiva
    Kridel, Steven J.
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2013, 14 (03) : 300 - 312
12345