Targeting fatty acid oxidation: A potential strategy for treating gastrointestinal tumors

被引：0
|
作者：
Zheng, Yingsong [1 ]
Jiang, Zhengchen [2 ]
Yuan, Li [3 ]
Cheng, Xiangdong [2 ]
He, Weiyang [4 ]
Chen, Xiaodong [4 ]
机构：
[1] Wenzhou Med Univ, Zhejiang Canc Hosp, Postgrad Training Base Alliance, Hangzhou, Peoples R China
[2] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Dept Gastr Surg, Hangzhou, Peoples R China
[3] Zhejiang Canc Hosp, Zhejiang Key Lab Prevent Diag & Therapy Upper Gast, Hangzhou, Peoples R China
[4] Univ Elect Sci & Technol China, Sichuan Canc Hosp & Inst, Sichuan Clin Res Ctr Canc, Dept Gastr Surg,Sichuan Canc Ctr,Affiliated Canc H, Chengdu 610041, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CANCER | 2025年
关键词：
CPT1; FAO; gastrointestinal tumor; ROS; tumor microenvironment; ALPHA-OXIDATION; BETA-OXIDATION; CELL SURVIVAL; CANCER-CELLS; METABOLISM; METASTASIS; TISSUE; PREADIPOCYTES; RESISTANCE; HYPOXIA;
D O I：
10.1002/ijc.35380
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastrointestinal cancers including esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), and colorectal cancer (CRC) are common and highly lethal types of cancer worldwide. Metabolic reprogramming plays a critical role in cancer progression and involves metabolic processes such as glucose and lipid metabolism. Fatty acid oxidation (FAO) has a profound impact on cancer, with many genes and cytokines influencing cancer cell initiation, development, metastasis, and resistance by regulating FAO. Additionally, FAO further promotes cancer progression by affecting the tumor microenvironment (TME). The role of FAO in gastrointestinal cancers has garnered increasing attention, and related anticancer drugs are currently being developed.
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页数：11
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