1H-NMR-based metabolomics identifies disrupted betaine metabolism as distinct serum signature of pre-frailty

被引：0

作者：

Carmen Marino ^{[1
]}

Alberto Imarisio ^{[2
]}

Clara Gasparri ^{[3
]}

Enza Napolitano ^{[4
]}

Anna Di Maio ^{[1
]}

Micol Avenali ^{[5
]}

Gabriele Buongarzone ^{[6
]}

Caterina Galandra ^{[7
]}

Marta Picascia ^{[8
]}

Manuela Grimaldi ^{[7
]}

Francesco Errico ^{[8
]}

Mariangela Rondanelli ^{[3
]}

Anna Maria D’Ursi ^{[8
]}

Enza Maria Valente ^{[1
]}

Alessandro Usiello ^{[6
]}

机构：

[1] Department of Pharmacy, University of Salerno, Fisciano, Salerno

[2] Department of Molecular Medicine, University of Pavia, Pavia

[3] Neurogenetics Research Centre, IRCCS Mondino Foundation, Pavia

[4] Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, Pavia

[5] Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Università degli Studi della Campania “Luigi Vanvitelli”, Caserta

[6] CEINGE Biotecnologie Avanzate Franco Salvatore, Naples

[7] Department of Brain and Behavioral Sciences, University of Pavia, Pavia

[8] Parkinson’s Disease and Movement Disorders Unit, IRCCS Mondino Foundation, Pavia

[9] Department of Agricultural Sciences, University of Naples “Federico II”, Portici

[10] Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia

来源：

npj Aging | / 11卷 / 1期

关键词：

D O I：

10.1038/s41514-025-00218-z

中图分类号：

学科分类号：

摘要：

Increasing evidence suggests that frailty results from a complex age-associated metabolic decline. Here, we investigated the serum metabolomic profile of a well-characterized cohort of elderly subjects encompassing the whole fit-to-frail continuum. Enrichment analyses revealed a complex dysregulation of amino acids and energy metabolism in both pre-frail and frail participants. Remarkably, upregulated betaine levels emerged as a specific biochemical signature of pre-frail females, holding promise for the development of novel targeted interventions. © The Author(s) 2025.

引用

共 39 条

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