Nivolumab-induced Thrombotic Thrombocytopenic Purpura in Patients with Gastric Tube Cancer

被引：0

作者：

Yoshida, Yuya ^{[1
]}

Toriyabe, Sakura ^{[1
]}

Imai, Hiroo ^{[1
]}

Sasaki, Keiju ^{[1
]}

Kasahara, Yuki ^{[1
]}

Ouchi, Kota ^{[1
]}

Saijo, Ken ^{[1
]}

Onodera, Koichi ^{[2
]}

Ishioka, Chikashi ^{[1
]}

机构：

[1] Tohoku Univ Hosp, Dept Med Oncol, Sendai, Japan

[2] Tohoku Univ Hosp, Dept Hematol, Sendai, Japan

来源：

INTERNAL MEDICINE | 2024年 / 63卷 / 19期

关键词：

thrombotic thrombocytopenic purpura; gastric tube cancer; hematological adverse events; nivolumab; immunotherapy-related adverse events; immune checkpoint inhibitor; ADVERSE EVENT; HEMOLYTIC-ANEMIA; CLINICAL-TRIALS; CASE SERIES;

D O I：

10.2169/internalmedicine.2931-23

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, immune checkpoint inhibitors (ICIs) have been used to treat several cancer types. ICIs have been reported to cause a wide variety of immune-related adverse events, including endocrine, neurologic, gastrointestinal, and cutaneous disorders. Thrombotic thrombocytopenic purpura (TTP) is an autoimmune hematologic disorder characterized by the presence of autoantibodies against a disintegrin and metalloprotease with thrombospondin-1, member 13. Several previous cases of TTP were thought to have been caused by ICI treatment. We herein report a rare case of TTP that developed after long-term treatment with an ICI (nivolumab) for gastric tube cancer.

引用

页码：2667 / 2671

页数：5

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