AhR governs lipid metabolism: the role of gut microbiota

被引：0

作者：

Zheng, Wanru ^{[1
]}

Liu, Mengkuan ^{[1
]}

Lv, Xinyu ^{[1
]}

He, Cuimei ^{[1
]}

Yin, Jie ^{[2
]}

Ma, Jie ^{[1
]}

机构：

[1] Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China

[2] Hunan Agr Univ, Coll Anim Sci, Changsha, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2025年 / 16卷

关键词：

aryl hydrocarbon receptor; gut microbiota; lipid metabolism; inflammation; metabolic disease; ARYL-HYDROCARBON RECEPTOR; DIETARY AMINO-ACIDS; HEPATIC STEATOSIS; FATTY LIVER; OBESITY; INHIBITION; PROTECTS; MICE; DIFFERENTIATION; ACCUMULATION;

D O I：

10.3389/fmicb.2025.1442282

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Aryl Hydrocarbon Receptor (AhR) is widely present in mammalian bodies, showing high affinity for various exogenous substances such as polycyclic aromatic hydrocarbons (PAHs) and coumarin. Under physiological conditions, AhR mainly participates in regulating the body's immune response, cell proliferation, and apoptosis among a series of processes. Recent studies have revealed a close connection between AhR and lipid metabolism. The gut microbiota plays a significant role in regulating host lipid metabolism. Growing evidence suggests an inseparable link between gut microbiota and AhR signaling. This review summarizes the relationship between AhR and lipid metabolism disorders, as well as the interaction between gut microbiota and AhR, exploring how this interaction modulates host lipid metabolism.

引用

页数：11

共 50 条

[21] Sex differences in lipid metabolism are affected by presence of the gut microbiota
Annemarie Baars
Annemarie Oosting
Mirjam Lohuis
Martijn Koehorst
Sahar El Aidy
Floor Hugenholtz
Hauke Smidt
Mona Mischke
Mark V. Boekschoten
Henkjan J. Verkade
Johan Garssen
Eline M. van der Beek
Jan Knol
Paul de Vos
Jeroen van Bergenhenegouwen
Floris Fransen
Scientific Reports, 8
[22] Sex differences in lipid metabolism are affected by presence of the gut microbiota
Bears, Annemarie
Oosting, Annemarie
Lohuis, Mirjam
Koehorse, Martijn
El Aidy, Sahar
Hugenholtz, Floor
Smidt, Hauke
Mischke, Mona
Boekschoten, Mark V.
Verkade, Henkjan J.
Garssen, Johan
van der Beek, Eline M.
Knol, Jan
de Vos, Paul
van Bergenhenegouwen, Jeroen
Fransen, Floris
SCIENTIFIC REPORTS, 2018, 8
[23] Lipid metabolism and nutritive factors of the gut microbiota in human foragers
Schnorr, Stephanie L.
Henry, Amanda G.
Crittenden, Alyssa N.
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 2016, 159 : 283 - 283
[24] Gut Microbiota Influence Lipid Metabolism of Skeletal Muscle in Pigs
Wu, Choufei
Lyu, Wentao
Hong, Qihua
Zhang, Xiaojun
Yang, Hua
Xiao, Yingping
FRONTIERS IN NUTRITION, 2021, 8
[25] Effects of Consuming Xylitol on Gut Microbiota and Lipid Metabolism in Mice
Uebanso, Takashi
Kano, Saki
Yoshimoto, Ayumi
Naito, Chisato
Shimohata, Takaaki
Mawatari, Kazuaki
Takahashi, Akira
NUTRIENTS, 2017, 9 (07)
[26] Role of Gut Microbiota in the Metabolism and Bioactivity of Saffron Apocarotenoids
Garcia-Villalba, R.
Garcia, C. J.
Beltran, D.
Frutos-Lison, M. D.
Garcia-Conesa, M. T.
Tomas-Barberan, F. A.
ANNALS OF NUTRITION AND METABOLISM, 2024, 80 : 24 - 25
[27] The role of the gut microbiota in neurodegenerative diseases targeting metabolism
Fu, Yufeng
Gu, Zhongya
Cao, Huan
Zuo, Chengchao
Huang, Yaqi
Song, Yu
Jiang, Yongsheng
Wang, Furong
FRONTIERS IN NEUROSCIENCE, 2024, 18
[28] The role of gut microbiota on the metabolism of black tea theaflavins
Zhang, Shuwei
Ohland, Christina L.
Jobin, Christian
Sang, Shengmin
FASEB JOURNAL, 2017, 31
[29] Human gut microbiota plays a role in the metabolism of drugs
Jourova, Lenka
Anzenbacher, Pavel
Anzenbacherova, Eva
BIOMEDICAL PAPERS-OLOMOUC, 2016, 160 (03): : 317 - 326
[30] The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease
Cani, Patrice D.
Delzenne, Nathalie M.
CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (13) : 1546 - 1558

← 1 2 3 4 5 →