Localized large B-cell lymphoma with MYC and BCL6 rearrangements as an unexpected finding in an appendectomy specimen

被引：0

作者：

Poltorak, Przemyslaw Marcin ^{[1
]}

Plesner, Trine Lindhardt ^{[2
]}

Petersson, Eva Stampe ^{[2
]}

Schejbel, Lone ^{[3
]}

Breinholt, Marie Fredslund ^{[3
]}

Lode, Lise ^{[4
]}

Hutchings, Martin ^{[5
]}

Norgaard, Peter ^{[1
]}

机构：

[1] Univ Copenhagen, Dept Pathol, Hosp Hvidovre, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark

[2] Rigshosp, Copenhagen Univ Hosp, Dept Pathol, Copenhagen, Denmark

[3] Univ Copenhagen, Dept Pathol, Hosp Herlev, Herlev, Denmark

[4] Univ Copenhagen, Surg Sect, Gastrounit, Hosp Hvidovre, Hvidovre, Denmark

[5] Rigshosp, Copenhagen Univ Hosp, Dept Haematol, Copenhagen, Denmark

来源：

APMIS | 2025年 / 133卷 / 01期

关键词：

Appendix; double-hit lymphoma; HGBL; c-myc; bcl6; HEALTH-ORGANIZATION CLASSIFICATION; OUTCOMES;

D O I：

10.1111/apm.13492

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Large B-cell lymphomas (LBLs) comprise a genetically heterogeneous group of clinically aggressive non-Hodgkin lymphomas, frequently exhibiting overlapping features with diffuse large B-cell lymphoma and Burkitt's lymphoma. We report a case of a 24-year-old, previously healthy male with a classical clinical presentation of acute appendicitis. The pathologic examination discovered a large B-cell lymphoma with MYC and BCL6 rearrangements in the excised appendix. The patient was assigned Stage IEA, IPI = 0 and received chemotherapy. This case depicts a very uncommon occurrence of fully localized LBL in a patient of an unusually young age and clinical presentation for this type of lymphoma.

引用

页数：4

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