Localized large B-cell lymphoma with MYC and BCL6 rearrangements as an unexpected finding in an appendectomy specimen

被引：0
|
作者：
Poltorak, Przemyslaw Marcin [1 ]
Plesner, Trine Lindhardt [2 ]
Petersson, Eva Stampe [2 ]
Schejbel, Lone [3 ]
Breinholt, Marie Fredslund [3 ]
Lode, Lise [4 ]
Hutchings, Martin [5 ]
Norgaard, Peter [1 ]
机构：
[1] Univ Copenhagen, Dept Pathol, Hosp Hvidovre, Kettegaard Alle 30, DK-2650 Hvidovre, Denmark
[2] Rigshosp, Copenhagen Univ Hosp, Dept Pathol, Copenhagen, Denmark
[3] Univ Copenhagen, Dept Pathol, Hosp Herlev, Herlev, Denmark
[4] Univ Copenhagen, Surg Sect, Gastrounit, Hosp Hvidovre, Hvidovre, Denmark
[5] Rigshosp, Copenhagen Univ Hosp, Dept Haematol, Copenhagen, Denmark
来源：
APMIS | 2025年 / 133卷 / 01期
关键词：
Appendix; double-hit lymphoma; HGBL; c-myc; bcl6; HEALTH-ORGANIZATION CLASSIFICATION; OUTCOMES;
D O I：
10.1111/apm.13492
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Large B-cell lymphomas (LBLs) comprise a genetically heterogeneous group of clinically aggressive non-Hodgkin lymphomas, frequently exhibiting overlapping features with diffuse large B-cell lymphoma and Burkitt's lymphoma. We report a case of a 24-year-old, previously healthy male with a classical clinical presentation of acute appendicitis. The pathologic examination discovered a large B-cell lymphoma with MYC and BCL6 rearrangements in the excised appendix. The patient was assigned Stage IEA, IPI = 0 and received chemotherapy. This case depicts a very uncommon occurrence of fully localized LBL in a patient of an unusually young age and clinical presentation for this type of lymphoma.
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