Efficacy of stem cell therapy in patients with chronic liver disease: an umbrella review of systematic reviews

被引：0

作者：

Teng, Yue ^{[1
]}

Gaidhane, Abhay M. ^{[2
,3
]}

Padhi, Bijaya K. ^{[4
,5
]}

Zahiruddin, Quazi S. ^{[6
]}

Alhumaid, Saad ^{[7
]}

Sharma, Rakesh K. ^{[8
,9
]}

Rustagi, Sarvesh ^{[10
]}

Satapathy, Prakasini ^{[11
]}

Sharma, Divya ^{[12
]}

Arora, Mithhil ^{[13
]}

Hazazi, Ali ^{[14
,15
]}

Alturaifi, Amani ^{[16
]}

Alrshoud, Mansoor A. ^{[16
]}

Zaidan, Ali A. ^{[17
]}

Almosa, Fadel A. M. ^{[18
]}

Alzayer, Suha A. ^{[19
]}

Alqam, Razi Al ^{[19
]}

Alhajaji, Raghad ^{[20
]}

Rabaan, Ali A. ^{[15
,21
,22
]}

机构：

[1] Swansea Univ, Fac Med Hlth & Life Sci, Swansea, Wales

[2] Datta Meghe Inst HIgher Educ & Res, Jawaharlal Nehru Med Coll, Wardha, India

[3] Global Hlth Acad, Datta Meghe Inst Higher Educ, Sch Epidemiol andPubl Hlth, Wardha, India

[4] Postgrad Inst Med Educ & Res, Dept Community Med, Chandigarh, India

[5] Postgrad Inst MedicalEducat & Res, Sch Publ Hlth, Chandigarh, India

[6] South Asia Infant Feeding Res Network SAIFRN, Global Consortium Publ Hlth & Res, Datta Meghe Inst Higher Educ, Div Evidence Synth, Wardha 442107, India

[7] Univ Tasmania, Sch Pharm, Hobart, Australia

[8] Graph Era Deemed Be Univ, Clement Town, Dehradun, India

[9] Graph Era Hill Univ, Clement Town, Dehradun, India

[10] Uttaranchal Univ, Sch Appl & Life Sci, Dehra Dun, India

[11] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai, India

[12] Chitkara Univ, Ctr Res Impact & Outcome, Rajpura, Punjab, India

[13] Chitkara Univ, Chitkara Ctr Res & Dev, Himachal Pradesh, India

[14] Secur Forces Hosp Program, Dept Lab Med, Riyadh 11481, Saudi Arabia

[15] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia

[16] Riyadh Reg Lab, Lab Total Qual Management Dept, Riyadh, Saudi Arabia

[17] King Fahad Armed Forces Hosp, Gastroenterol Dept, Jeddah, Saudi Arabia

[18] Qatif Cent Hosp, Dept Internal Med, Gastroenterol Unit, Minist Hlth, Qatif, Saudi Arabia

[19] Qatif Comprehens Inspection Ctr, Lab Dept, Qatif, Saudi Arabia

[20] Minist Hlth, Med Genet Unit, Matern & Children Hosp, Makkah Healthcare Cluster, Mecca 24382, Saudi Arabia

[21] Johns Hopkins Aramco Hlthcare, Mol Diagnost Lab, Dhahran, Saudi Arabia

[22] Univ Haripur, Dept Publ Hlth & Nutr, Haripur, Pakistan

来源：

INTERNATIONAL JOURNAL OF SURGERY | 2024年 / 110卷 / 11期

关键词：

chronic liver disease; liver cirrhosis; meta-analysis; stem cells; umbrella review; COLONY-STIMULATING FACTOR; TRANSPLANTATION; CIRRHOSIS; FAILURE; METAANALYSIS; INJECTION;

D O I：

10.1097/JS9.0000000000001644

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background:Stem cell therapy offers promising benefits like modulating immune responses, reducing inflammation, and aiding liver regeneration. This umbrella review seeks to compile evidence from systematic reviews to assess the efficacy of stem cell therapy for improving liver function and survival rates in chronic liver disease patients.Methods:We searched electronic databases up to February 15, 2024. The selection process focused on systematic reviews comparing stem cell therapy with standard care or a placebo. The primary outcomes evaluated were changes in liver enzymes, the Model for End-Stage Liver Disease score, and survival rates. Nested Knowledge software was utilized for screening and data extraction. All statistical analyses were performed using R software, version 4.3.Results:Our umbrella review included 28 systematic reviews. The meta-analysis showcased a notable improvement in survival rates with a pooled relative risk of 1.487 [95% confidence interval (CI): 1.281-1.727). In nonrandomized studies, albumin levels exhibited a standardized mean difference (SMD) of 0.786 (95% CI: 0.368-1.204), indicating positive therapeutic effects. For alanine aminotransferase, the meta-analysis revealed a decrease in levels with an SMD of -0.499 (95% CI: -0.834 to -0.164), and for aspartate aminotransferase, an overall SMD of -0.362 (95% CI: -0.659 to -0.066) was observed, suggesting hepatoprotective effects. No significant changes were observed in total bilirubin levels and Model for End-Stage Liver Disease scores in randomized controlled trials.Conclusion:Stem cell therapy exhibits potential as a novel treatment for chronic liver diseases, as it has demonstrated improvements in survival rates and certain liver function markers. More high-quality randomized controlled trials are needed in the future to fully ascertain the efficacy of stem cell therapy in this patient population.

引用

页码：6848 / 6861

页数：14