Induction chemotherapy followed by chemoradiation in locally advanced cervical cancer: Quality of life outcomes of the GCIG INTERLACE trial

被引:3
作者
Eminowicz, G. [1 ]
Vaja, S. [2 ,3 ]
Gallardo, D. [4 ]
Kent, C. [5 ]
Panades, M. [6 ]
Mathew, T. [7 ]
Anand, A. [8 ]
Forrest, J. [9 ]
Adusumalli, M. [10 ]
Chan, A. [2 ,3 ]
Hacker, A. M. [2 ,3 ]
Hackshaw, A. [2 ,3 ]
Ledermann, J. A. [2 ,3 ]
McCormack, M. [1 ]
机构
[1] Univ Coll Hosp NHS Trust, London, England
[2] Canc Res UK, London, England
[3] UCL Canc Inst, UCL Canc Trials Ctr, London, England
[4] Inst Nacl Cancerl, Mexico City, Mexico
[5] Univ Leicester NHS Trust, Leicester, England
[6] United Lincolnshire Hosp NHS Trust, Grantham, England
[7] Sheffield Teaching Hosp NHS Trust, Sheffield, England
[8] Nottingham Univ NHS Trust, Nottingham, England
[9] Royal Devon Univ Hosp NHS Fdn Trust, Exeter, England
[10] South Tees Hosp NHS Fdn Trust, Middlesbrough, England
关键词
Quality of life; Cervical cancer; Chemoradiotherapy; Induction chemotherapy; EUROPEAN-ORGANIZATION; CISPLATIN; RADIATION;
D O I
10.1016/j.ejca.2025.115375
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim: Induction chemotherapy (IC) added to chemoradiation (CRT) in locally advanced cervical cancer (LACC) improves survival at the expense of adverse events (AEs), 99 % with IC/CRT vs 95 % CRT alone, 59 % vs 48 % G3/4 AEs. We investigated the impact of this on quality of life (QoL). Methods: 500 women with FIGO 2008 stage IB1 node positive, IB2, II, IIIB and IVA cervical carcinoma were randomised to CRT alone or IC (6 weeks carboplatin AUC2 paclitaxel 80mg/m2) followed by CRT. QoL questionnaires (EORTC QLQ-C30 v3, QLQ-CX24) were completed at baseline, D1 week 4 IC, D1 CRT, D1 week 3 CRT, 4 weeks post CRT and all follow up visits. Mixed modelling for repeated measures was used to compare the groups during trial treatment to 2 years follow up (adjusting for baseline). Results: QoL (global health status, physical and social functioning) slightly worsened during IC and symptom experience slightly improved. Emotional functioning improved during IC. Peripheral neuropathy was slightly worse with IC/CRT. Fatigue and nausea/vomiting worsened from baseline to week 4 IC whilst pain and diarrhoea improved, consistent with reported AEs. Over the whole period, mean differences for these symptoms between the treatment groups was small and not clinically significant and resolved by 12-18 months. In all cases, mean score differences during trial treatment until 2 years post CRT showed only small differences (<5 units) not meeting the threshold for clinical relevance. Conclusion: IC added to CRT does not adversely impact QoL compared to CRT, either during IC, during CRT or later.
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页数:8
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