Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke

被引：0
作者：
Xu, Weilin [1 ,2 ]
Yan, Jun [3 ]
Travis, Zachary D. [4 ]
Lenahan, Cameron [5 ]
Gao, Liansheng [1 ,2 ]
Wu, Haijian [1 ,2 ]
Zheng, Jingwei [1 ,2 ]
Zhang, Jianmin [1 ,2 ]
Shao, Anwen [1 ,2 ]
Yu, Jun [1 ,2 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurosurg, Hangzhou, Zhejiang, Peoples R China
[2] Key Lab Precise Treatment & Clin Translat Res Neur, Hangzhou, Zhejiang, Peoples R China
[3] Guangxi Med Univ, Dept Neurosurg, Affiliated Tumor Hosp, Nanning, Peoples R China
[4] Western Univ Hlth Sci, Coll Hlth Sci, Dept Med Sci Educ, Pomona, CA USA
[5] New Mexico State Univ, Burrell Coll Osteopath Med, Las Cruces, NM USA
来源：
FRONTIERS IN PHARMACOLOGY | 2025年 / 15卷
基金：
中国国家自然科学基金;
关键词：
apelin; APJ; stroke; oxidative stress; neuroprotection; ENDOPLASMIC-RETICULUM STRESS; VASCULAR SMOOTH-MUSCLE; ORPHAN RECEPTOR APJ; OXIDATIVE STRESS; ENDOGENOUS LIGAND; NITRIC-OXIDE; MESSENGER-RNA; DEPENDENT REGULATION; TISSUE DISTRIBUTION; SIGNALING PATHWAY;
D O I：
10.3389/fphar.2024.1352927
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways. Despite this, the clinical application of the apelin/APJ system remains distant, as apelin has numerous active forms and signaling pathways. The development of a range of drugs targeting the apelin/APJ system holds promise for treating stroke.
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页数：10
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