Apelin/APJ system: a novel promising target for anti-oxidative stress in stroke

被引：0

作者：

Xu, Weilin ^{[1
,2
]}

Yan, Jun ^{[3
]}

Travis, Zachary D. ^{[4
]}

Lenahan, Cameron ^{[5
]}

Gao, Liansheng ^{[1
,2
]}

Wu, Haijian ^{[1
,2
]}

Zheng, Jingwei ^{[1
,2
]}

Zhang, Jianmin ^{[1
,2
]}

Shao, Anwen ^{[1
,2
]}

Yu, Jun ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurosurg, Hangzhou, Zhejiang, Peoples R China

[2] Key Lab Precise Treatment & Clin Translat Res Neur, Hangzhou, Zhejiang, Peoples R China

[3] Guangxi Med Univ, Dept Neurosurg, Affiliated Tumor Hosp, Nanning, Peoples R China

[4] Western Univ Hlth Sci, Coll Hlth Sci, Dept Med Sci Educ, Pomona, CA USA

[5] New Mexico State Univ, Burrell Coll Osteopath Med, Las Cruces, NM USA

来源：

FRONTIERS IN PHARMACOLOGY | 2025年 / 15卷

基金：

中国国家自然科学基金;

关键词：

apelin; APJ; stroke; oxidative stress; neuroprotection; ENDOPLASMIC-RETICULUM STRESS; VASCULAR SMOOTH-MUSCLE; ORPHAN RECEPTOR APJ; OXIDATIVE STRESS; ENDOGENOUS LIGAND; NITRIC-OXIDE; MESSENGER-RNA; DEPENDENT REGULATION; TISSUE DISTRIBUTION; SIGNALING PATHWAY;

D O I：

10.3389/fphar.2024.1352927

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The apelin/APJ system has garnered increasing attention in recent years. In this review, we comprehensively discuss the physiological and pathological mechanisms of the apelin/APJ system in stroke. The apelin/APJ system is widely expressed in the central nervous system (CNS). However, the distribution of the apelin/APJ system varies across different regions and subcellular organelles of the brain. Additionally, the neuroprotective effects of the apelin/APJ system have been reported to inhibit oxidative and nitrative stresses via various signaling pathways. Despite this, the clinical application of the apelin/APJ system remains distant, as apelin has numerous active forms and signaling pathways. The development of a range of drugs targeting the apelin/APJ system holds promise for treating stroke.

引用

页数：10

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